fatty change

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Related to fatty change: fatty metamorphosis

fat·ty met·a·mor·pho·sis

the appearance of microscopically visible droplets of fat in the cytoplasm of cells.
See also: fatty degeneration.
Synonym(s): fatty change


A pattern of reversible cell injury resulting from hypoxia, toxic or metabolic insults, diabetes mellitus, obesity, and protein malnutrition, which consists of an accumulation of droplets of triglcerides/neutral fat in various solid organs—classically, the liver—and most common in alcoholics in whom the changes regress with abstention from alcohol. Fatty changes may also occur in other organs (e.g., heart, muscle, kidney).

fatty change

Any abnormal accumulation of fat within parenchymal cells. It may occur in the heart or other organs. When seen in the liver, it often is a result of excessive and prolonged alcohol intake or obesity.
References in periodicals archive ?
Although, as first stated, acceptance of this association of alcohol with marked fatty changes of the liver has in these various ways become general, no such agreement has as yet been arrived at with regard to symptoms enabling an estimate clinically of the degree to which the liver has suffered such alterations, and this notwithstanding the attention this phase of the subject has received since Louis (6) first called attention to marked fatty changes of the liver and especially its association with tuberculosis.
The diagnosis was: marked fatty changes of the liver; moderate edema of the leptomeninges; hyperplasia of the spleen; marked passive hyperemia of the kidneys and bowel lining; sclerosis of the aorta and front mitral leaflet; submucous minute petechial hemorrhages of the pancreatic duct; varicose veins of the lower extremities; slight anasarca (ankles); acute catarrhal conjunctivitis; fibrous adhesions between the liver and diaphragm, spleen and diaphragm, and spleen and liver.
The crude liver weight, which was increased after PCM administration may be due to haemorrhages, hydropic degeneration and fatty changes associated with necrosis.
Pretreatment with polyherbal drugs restored the hepatic architecture and protected the liver tissue from fatty and degenerative changes, by preventing the toxic chemical reaction, oxidative stress, lipid peroxidation, molecular changes in the liver tissues, micro and macro vesicular fatty changes ultimately leading to necrosis (25-30).
These fatty changes can be reversed but if they're not spotted can lead to cirrhosis and in some cases liver cancers.
A few animals treated with Aspirin showed mild fatty changes in the cardiac muscle fibers of heart and mild catarrhal changes of gastric mucosa, whereas, none of the animals treated with PLATROL(R) showed any such change.