At age 12, she presented marked muscular weakness and fatigability
, especially in the lower limbs.
Marked, rapid physical and/or cognitive fatigability
in response to exertion 2.
is the magnitude of a change in the performance level in a given time or the measure of mechanical production based on a reference value (Kluger et al.
Common Affected Systems and Signs of Mitochondrial Disease Neurologic Encephalopathy, seizures, developmental disability, cognitive disability migraines, stroke-like events, ataxia, spasticity dystonia, progressive sensorineural hearing impairment Cardiovascular Cardiomyopathy conduction defects, arrhythmias Opthalmologic Opthalmoplegia, ptosis, optic atrophy, retinitis pigmentosa Musculoskeletal Fatigability
, exercise intolerance, hypotonia Gastrointestinal Recurrent vomiting, constipation, pseudo-obstructions, dysphagia Endocrine Short stature, diabetes mellitus, exocrine pancreatic failure, thyroid dysregulation Note: Adapted from Kisler, Whittaker, & McFarland, 2010.
11,12) One proposed mechanism is reduced endurance and increased fatigability
of the trunk muscles, (13,14) which aid in stabilizing the spine.
Patients ranked fatigue or weakness (24%), easy fatigability
(16%), nausea or vomiting (12%) and pruritus (11%) as the four (4) most distressing symptom of CKD (Figure 1).
The results also showed that the improvements in IDS score focused on 5 of the score's 30 individual items: panic and phobic symptoms, appetite, concentration and decision making, energy and fatigability
and leaden paralysis and physical energy In contrast, armodafmil had no apparent effect on core symptoms of depression.
Sex differences in the fatigability
of arm muscles depends on absolute force during isometric contractions, Journal of Applied Physiology 91(6): 2686-2694.
PMS was diagnosed by presence of five or more symptoms below, one of first four in the list was indispensable: 1) emotional lability, 2) manic depression, 3) anxiety and tension, 4) mood deterioration, desperation, 5) lack of interest in daily life, 6) undue fatigability
, weakness, 7) trouble concentrating, 8) food cravings, susceptibility to bulimia, 9) somnolence or insomnia, 10) physical symptoms including breast tenderness, headaches, swellings, weight gain, myalgia, arthralgia (New PMS guidelines, 2000; Steiner M.
A detailed history was taken about lymphadenopathy, fever, bleeding from any site, breathlessness on mild exertion and easy fatigability
Due to the significant nasal breathing problems, the children complained about rapid fatigability
A 8-year-old male patient presented to our clinic with dyspnea and easy fatigability
in December 2009.