Only one patient had a clinical picture consistent with familial hyperlipidemia
, and this patient was identified based on risk factors and not age alone.
It has been reported that there are high-density lipoprotein (HDL) and LDL binding sites on platelets, and those binding sites are reduced in familial hyperlipidemia (7), (8).
Binding of 111In-labeled HDL to platelets from normolipidemic volunteers and patients with heterozygous familial hyperlipidemia.
It is reported that aortic atherosclerosis is often present in patients with homozygous familial hyperlipidemia, but its incidence is rare in heterozygous patients (8).
We noted that the mean age of patients in our study was much lower in comparison to the studies which underline the role of plasma cholesterol levels, hypertension and other factors as independent predictors (5, 12, 13) Conversely, although the mean age of patients with familial hyperlipidemia (8) was much lower than of our patients, their mean cholesterol levels were significantly higher.
Secondary causes of hyperlipidemia include diabetes mellitus, Cushing's disease, familial hyperlipidemia
, hypothyroidism, hypogonadism, obesity, and liver and renal disease (Calza et al.
Unless children are homozygous for one of the genetic defects associated with familial hyperlipidemia, they may not have signs or symptoms until they reach their twenties or thirties.
Emphasize to parents that familial hyperlipidemia is one of the preventable forms of heart disease.
We treat pediatric patients all the time," he said, "not only those with familial hyperlipidemias
but also those with metabolic syndrome.