familial histiocytic reticulosis

reticulosis /re·tic·u·lo·sis/ (rĕ-tik″u-lo´sis) an abnormal increase in cells derived from or related to the reticuloendothelial cells.

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familial histiocytic reticulosis , histiocytic medullary reticulosis a fatal hereditary disorder marked by anemia, granulocytopenia, thrombocytopenia, phagocytosis of blood cells, diffuse proliferation of histiocytes, and enlargement of the liver, spleen, and lymph nodes.

malignant midline reticulosis , polymorphic reticulosis a form of angiocentric immunoproliferative lesion involving midline structures of the nose and face.

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familial histiocytic reticulosis

Etymology: L, familia, household; Gk, histion, web, kytos, cell; L, reticulum, little net; Gk, osis, condition

a hereditary disease, transmitted as an autosomal-recessive trait, characterized by anemia, granulocytopenia, and thrombocytopenia. Phagocytosis of blood cells and infiltration of bone marrow by histiocytes commonly cause death in childhood. Also called familial hemophagocytic reticulosis.