Zuelzer, Wolf W.

(redirected from familial eosinophilia)


Wolf W., U.S. hematologist, 1909–.
Zuelzer syndrome - autosomal recessive trait characterized by the association of eosinophilia, leukocytosis, and hypergammaglobulinemia in infants and young children. Synonym(s): familial eosinophilia
Zuelzer-Ogden syndrome - hematologic disorder in infants. Synonym(s): megaloblastic anemia in infants
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Rare congenital syndromes can also enter into the differential diagnosis of eosinophilia, especially in children, and include hyper-IgE syndrome, Omenn syndrome, and familial eosinophilia.
Differential Diagnosis of Eosinophilia Common reactions: medications, parasites, asthma/allergy Adrenal insufficiency due to critical illness Multiorgan autoimmune/idiopathic diseases, especially EGPA/Churg-Strauss syndrome Single-organ eosinophilic diseases, especially lung, GI, skin Myeloid neoplasms with eosinophilia Secondary eosinophilia due to lymphoid or epithelial neoplasms Congenital syndromes: hyper-IgE, Omenn syndrome, familial eosinophilia Abbreviations: EGPA, eosinophilic granulomatosis with polyangiitis; GI, gastrointestinal disease; IgE, immunoglobulin E.
Although the causative mutation has not been cloned, familial eosinophilia is inherited in an autosomal-dominant fashion and, in at least one kindred group, maps to the long arm of chromosome 5, in a region where genes encoding IL-3, IL-5, and granulocyte macrophage colony-stimulating factor are all known to reside.
Disseminated eosinophilic collagenosis and familial eosinophilia.
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