familial dysalbuminemic hyperthyroxinaemia

familial dysalbuminemic hyperthyroxinaemia

An inherited form (OMIM:103600) of euthyroid hyperthyroxinaemia, which is characterised by an increased affinity of albumin for T4. It is the most common cause of inherited euthyroid hyperthyroxinaemia in Caucasians .

Molecular pathology
FDH is caused by a mutation of ALB  on chromosome 4q13.3.
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References in periodicals archive ?
Potential causes of spurious TFT results include nonspecific binding of endogenous circulating factors, such as heterophilic antibodies, with assay reagents (1), the presence of albumin variants found in familial dysalbuminemic hyperthyroxinaemia (2), and thyroid hormone autoantibodies (THAA) (3).
A screening test for familial dysalbuminemic hyperthyroxinaemia (4) was also negative.

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