familial combined hyperlipidemia

hyperlipidemia /hy·per·lip·id·emia/ (-lip″ĭ-de´me-ah) elevated concentrations of any or all of the lipids in the plasma, including hypertriglyceridemia, hypercholesterolemia, etc.hyperlipide´mic

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combined hyperlipidemia  a generic designation for a hyperlipidemia in which several classes of lipids are elevated; usually used to denote the phenotype of a type II-b hyperlipoproteinemia.

familial combined hyperlipidemia  an inherited disorder of lipoprotein metabolism manifested in adulthood as hypercholesterolemia, hypertriglyceridemia, or a combination, with elevated plasma apolipoprotein B and premature coronary atherosclerosis.

mixed hyperlipidemia  see under hyperlipemia.

remnant hyperlipidemia  a form in which the accumulated lipoproteins are normally transient intermediates, chylomicron remnants, and intermediate-density lipoproteins; a generic descriptor for the type III hyperlipoproteinemia phenotype.

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familial combined hyperlipidemia

Metabolic disease A common–1:300 AD disorder with ↑ TGs and/or cholesterol Lab ↑ apoB, ↑ LDL-C, ↑ VLDL-C, mild ↓ HDL-C, apoA1 Clinical CAD, first MI as early as age 40, overweight, HTN Management Diet–weight loss, exercise, lipid-lowering drugs; smoking is forbidden as it exacerbates ASHD