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familial aggregation

   Also found in: Dictionary/thesaurus, Legal, Financial, Encyclopedia, Wikipedia 0.01 sec.
aggregation /ag·gre·ga·tion/ (ag″rĕ-ga´shun)
1. massing or clumping of materials or people together.
2. a clumped mass of material.

familial aggregation  the occurrence of more cases of a given disorder in close relatives of a person with the disorder than in control families.
platelet aggregation  a clumping together of platelets induced by various agents (e.g., thrombin) as part of the mechanism leading to thrombus formation.

familial aggregation
n.
Occurrence of a trait in more members of a family than can be readily accounted for by chance.

aggregation [ag″rĕ-ga´shun]
1. massing or clumping of materials together.
2. a clumped mass of material.
familial aggregation the occurrence of more cases of a given disorder in close relatives of a person with the disorder than in control families.
platelet aggregation platelet agglutination.

aggregation
1. massing or clumping of materials together.
2. a clumped mass of material.

familial aggregation
the occurrence of more cases of a given disorder in close relatives of an animal with the disorder than in control families.
platelet aggregation
platelet agglutination.


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Studies of familial aggregation, different incidence rates in different racial and ethnic groups, and segregation analysis are all consistent in pointing to a genetic contribution to renal disease.
In some populations with founder effects, BRCA1/2 mutations are far more frequent and account for a greater proportion of familial aggregation and breast cancer overall.
Bradley added that a number of recent studies have also shown a familial aggregation of pain sensitivity.
 
 
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