familial aggregation


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Related to familial aggregation: proband

aggregation

 [ag″rĕ-ga´shun]
1. massing or clumping of materials together.
2. a clumped mass of material.
familial aggregation the occurrence of more cases of a given disorder in close relatives of a person with the disorder than in control families.
platelet aggregation platelet agglutination.

fa·mil·i·al ag·gre·ga·tion

occurrence of a trait in more members of a family than can be readily accounted for by chance; presumptive but not cogent evidence of the operation of genetic factors.

fa·mil·i·al ag·gre·ga·tion

(fă-mil'ē-ăl ag'rĕ-gā'shŭn)
Occurrence of a trait in more members of a family than can be readily accounted for by chance; presumptive but not cogent evidence of the operation of genetic factors.

aggregation

1. massing or clumping of materials together.
2. a clumped mass of material.

familial aggregation
the occurrence of more cases of a given disorder in close relatives of an animal with the disorder than in control families.
platelet aggregation
platelet agglutination.
References in periodicals archive ?
This study confirms our initial hypothesis of the existence of familial aggregation of CKD in individuals with hypertension and/or type 2 diabetes mellitus, indicating that familial predisposition to these diseases is an independent risk factor for kidney failure within this sample of the Brazilian population.
Familial aggregation of renal disease in a population-based case-control study.
Familial aggregation of type 2 (non-insulin-dependent) diabetes mellitus in south India; absence of excess maternal transmission.
Maternal effect and familial aggregation in a type 2 diabetic Moroccan population.
cholerae O1 may not be generalizable to the more recently-emerged O139 serogroup (23); a familial aggregation study focused on this pathogen would be of interest.
In conclusion, we used a population-based demographic database to demonstrate the presence of familial aggregation of cholera in Matlab, Bangladesh.
Thus far, there has been no attempt to examine whether individual differences in coincidence timing skills exhibit familial aggregation.
7 and no shared environmental variance, for a univariate analysis our sample would have 95 percent power to reject the hypothesis of no familial aggregation and approximately 40 percent power to reject the hypothesis that the familial aggregation is due to shared environment.
Camilla Krogh, of the Statens Serum Insti-tut, Copenhagen, Denmark, and colleagues examined the familial aggregation of py-loric stenosis from monozygotic twins (derived from a single fertilized egg) to fourth-generation relatives in the population of Denmark.
Segregation analysis is a statistical methodology aimed at determining if a major gene or genes could cause the observed familial aggregation of a disease by comparing the fit of both genetic and nongenetic models to family data.

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