Major finding: In a study of people at 50% risk for developing familial Alzheimer's disease
(FAD), gene mutation carriers with a Clinical Dementia Rating (CDR) score of 0.
Lisa Mosconi - Hippocampal Metabolism In The Longitudinal Prediction Of Decline From Normal Cognition To MCI And AD (funder: National Institutes of Health/National Institute on Aging) -- Alison Godbolt - MR Spectroscopy Demonstrates Presymptomatic Changes In Familial Alzheimer's Disease
(funder: The Medical Research Council, UK) -- Neill Graff-Radford - Plasma AB Levels as a Premorbid Biomarker for Cognitive Decline, Mild Cognitive Impairment (MCI) and Alzheimer Disease (AD) (funders: National Institutes of Health/National Institute on Aging, and the Robert and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program) -- Henry Brodaty - What is the Best Dementia Screening Instrument for General Practitioners to Use?
The results from our study suggest a new route to explore for the treatment of familial Alzheimer's disease
and possibly the more common sporadic forms of Alzheimer's disease.
Using a specific, high-throughput technique to visualize neurons in their entirety and Neurome's proprietary microscopy software, individual neurons from the brains of these mice expressing the gene associated with familial Alzheimer's disease
were reconstructed and analyzed in 3-D.
Our current inventory includes banked collections in schizophrenia, Alzheimer's disease, major depression, cystic fibrosis, rheumatoid arthritis and we are adding controlled collections in mild cognitive impairment (MCI), bipolar I disorder, Parkinson's disease, type II diabetes, Alzheimer's disease (with CSF), liver disease and familial Alzheimer's disease
Washington, Apr 19 (ANI): Scientists at University of Virginia have developed a computational model to examine the role of certain proteins in the development of Familial Alzheimer's disease
(FAD), which affects people as young as 30.
Aberrant gamma-secretase cleavage of APP underlies the majority of early onset, familial Alzheimer's Disease
Our current inventory includes banked controlled collections in schizophrenia, Alzheimer's disease, major depression, cystic fibrosis, rheumatoid arthritis, and we are adding controlled collections in mild cognitive impairment (MCI), bipolar I disorder, Parkinson's disease, type 2 diabetes, Alzheimer's disease (with CSF) and familial Alzheimer's disease
Mutations in two presenilin proteins -- PS1 and PS2 -- have been identified as causing most cases of inherited, early-onset AD, also called familial Alzheimer's disease
Perry has served on the Ohio Governor's Task Force on Alzheimer's Disease and on the Scientific Advisory Boards of the Institute for the Study of Aging, Familial Alzheimer's Disease
Research Foundation, and the Alzheimer's Disease and Related Disorders Association.
The transgenic mouse models utilize an amyloid precursor protein (APP) gene construct analogous to a form seen in familial Alzheimer's disease
or the APP gene found in normal humans.