famciclovir


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Related to famciclovir: shingles

famciclovir

 [fam-si´klo-vir]
a prodrug of penciclovir that is converted to the active drug following administration, used in the treatment of herpes zoster, of genital herpes, and of mucocutaneous herpes simplex in immunocompromised patients; administered orally.

famciclovir

Apo-Famciclovir (CA), Famvir, PMS-Famciclovir (CA), Sandoz Famciclovir (CA)

Pharmacologic class: Synthetic nucleoside

Therapeutic class: Antiviral

Pregnancy risk category B

Action

Converts to penciclovir and selectively inhibits DNA polymerase and viral DNA synthesis

Availability

Tablets: 125 mg, 250 mg, 500 mg

Indications and dosages

Acute herpes zoster infection (shingles)

Adults: 500 mg P.O. q 8 hours for 7 days

Recurrent genital herpes in immunocompetent patients

Adults: 1,000 mg P.O. b.i.d. for 1 day, starting as soon as symptoms appear

Suppression of recurrent genital herpes

Adults: 250 mg P.O. b.i.d. for up to 1 year

Recurrent herpes simplex infection in patients with human immunodeficiency virus

Adults: 500 mg P.O. b.i.d. for 7 days

Herpes labialis (oral herpes simplex) in immunocompetent patients

Adults: 1,500 mg P.O. as a one-time dose given as soon as symptoms appear

Dosage adjustment

• Renal impairment

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in:
• renal or hepatic impairment
• elderly patients
• pregnant or breastfeeding patients
• children younger than age 18.

Administration

• Know that for best response, therapy should begin within 6 hours of onset of genital herpes symptoms or lesions.
• Give with or without food.

Adverse reactions

CNS: headache, fatigue, dizziness, drowsiness, paresthesia, insomnia

EENT: pharyngitis, sinusitis

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, anorexia

Musculoskeletal: back pain, joint pain

Skin: pruritus, rash

Other: fever

Interactions

Drug-drug.Digoxin: increased digoxin blood level, increased risk of toxicity

Probenecid: increased blood level of penciclovir (active antiviral compound of famciclovir)

Patient monitoring

• When giving concurrently with digoxin, monitor digoxin blood level and evaluate for digoxin toxicity.
• Monitor CBC, blood urea nitrogen, creatinine, and electrolyte levels.
• Be aware that drug may take several weeks to reach therapeutic level.
• Know that renal failure may raise blood drug level, increasing the risk of adverse reactions.
• Avoid direct contact with infected areas. Wash hands frequently and wear gloves during patient contact.

Patient teaching

• Instruct patient to take with food or milk to avoid upset stomach.
• Inform patient that drug doesn't cure herpes but only decreases pain and itching by allowing sores to heal and preventing new ones from forming.
• Advise patient to wear loose-fitting clothing to avoid irritating lesions.
• Tell patient to report rash or itching.
• Instruct female patient to tell prescriber if she is pregnant or breastfeeding.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

famciclovir

/fam·ci·clo·vir/ (fam-si´klo-vir) a prodrug of penciclovir used in the treatment of herpes zoster, of herpes genitalis, and of mucocutaneous herpes simplex in immunocompromised patients.

famciclovir

(făm-sī′klō-vîr′)
n.
A synthetic nucleoside analog, C14H19N5O4, used to treat herpes simplex and herpes zoster infections.

famciclovir

an antiviral drug.
indications It is prescribed in the treatment of acute herpes zoster and recurrent genital herpes.
contraindications It should not be given to patients with kidney disease or an allergy to famciclovir. The safety of the drug in children or in women who are pregnant or breastfeeding has not been established.
adverse effects The side effects most often reported include fatigue, fever, pain, chills, headache, dizziness, nausea, diarrhea, vomiting, and constipation.

famciclovir

An antiviral drug used to treat SHINGLES and genital HERPES. A brand name is Famvir.

Famciclovir

An oral antiviral drug that is available under the trade name Famvir. The drug blocks the replication of the varicella zoster virus.
Mentioned in: Shingles

famciclovir

(famsī´klōvēr),
n brand name: Famvir;
drug class: antiviral;
action: converted to active metabolite, peniciclovir triphosphate, which inhibits viral DNA synthesis and replication;
uses: acute herpes zoster (shingles) infection.
References in periodicals archive ?
14,15) Only 1 study compared the efficacy of famciclovir to valacyclovir for suppression and showed that valacyclovir was more effective.
Comparison between famciclovir and valacyclovir for acute pain in adult Japanese immunocompetent patients with herpes zoster.
In addition, there are also studies recommending oral valacyclovir and famciclovir, or intravenous foscarnet and gancyclovir as alternatives.
Famciclovir works similarly to acyclovir but only on herpes-infected cells (Vallerand et al.
This disease can be treated with one of the three FDA approved antiviral agents which are acyclovir, famciclovir, and valacyclovir.
Certain drugs have been proposed for the treatment of FeHV-1 ocular infections, including bromovinyldeoxyuridine, cidofovir, famciclovir, N-(2-hydroxy propyl) methacrylamide (HPMA), penciclovir, ribavirin, valacyclovir, vidarabine, foscarnet and lactoferrin (MALIK et al.
Nonantiretrovirals requiring dose adjustment with declining kidney function * * Acyclovir * Adefovir * Amphotericin B * Cidofovir * Ciprofloxacin * Clarithromycin * Ethambutol * Famciclovir * Fluconazole * Flucytosine * Foscarnet * Ganciclovir * Isoniazid * Levofloxacin * Pentamidine * Pyrazinamide * Peginterferon alfa-2a * Peginterferon alfa-2b * Ribavirin * Rifabutin * Rifampin * Sulfadiazine * Trimethoprim/sulfamethoxazole * Valacyclovir * Valganciclovir * Source: HIVMA/IDSA CKD guidelines.
The risk of stroke was greatest among those with ophthalmic shingles and was lower in those treated with antiviral medications, such as acyclovir (Zovirax[R]) and famciclovir (Famvir[R]), the study authors noted.
Iguales resultados se han encontrado con famciclovir 500 mg cada 8 h por 7 dias.
We plan to launch the following by the end of 2013: Lisinopril, meclizine, ababcavir sulfate, famciclovir, montelukast sodium, pantoprazole Na, phentermine HC1 tablets and capsules, olanzapine and zolmitriptan," notes Ostaficiuk.
Patients treated with vincristine-adriamycin-dexamethasone (VAD), high-dose dexamethasone, or a bortezomib-based regimens who are at high risk of reactivation or new acquisition of herpetic infections should receive antiviral prophylaxis with oral acyclovir, at 800 mg 4 times daily, or one of the newer antiviral drugs such as famciclovir or valacyclovir (32).
Acyclovir (Zovirax), valacyclovir (Valtrex) and famciclovir (Famvir) are all prescription antiviral drugs that are effective in treating genital herpes.