As a result of this strategy, we find the lot-to-lot variations in the false-positive and false-negative rates
The known false-negative rate
of mammography is between 8% and 10%.
There is a high false-negative rate
in this situation , This has been contradicted by a study performed in Cremona, Italy, where researchers were able to show that neoadjuvant chemotherapy does not alter the location of sentinel lymph nodes and they demonstrated a high pick-up rate before and after neoadjuvant chemotherapy , A meta-analysis in support of SLNB post neoadjuvant therapy on 1273 patients from 21 small studies showed an overall SLN detection rate of 90%, sensitivity 88%, specificity 100%, and false-negative rate
of 12% , This compares very well with three meta-analyses of SLNB in patients who had not received neoadjuvant chemotherapy [25,26], with a highest detection rate of 96% and a false-negative rate
of 7% in one of the studies .
Compared with each adjusted QM, the unadjusted QM had a false-negative rate
of over 0.
Surface and bagged readings had false-negative rates
of 21 percent, well above the study performance criteria of five percent or less.
chi square] and Fisher exact tests were used to compare the efficiency, false-positive rate, false-negative rate
, and review rate between different sets of criteria.
So in essence, we're reducing the false-negative rate
from 26% down to 4%," he said.
Due primarily to tumor heterogeneity, the false-negative rate
for the HER2 test, particularly by immunohistochemistry (IHC), is estimated to be 10-15% or higher; the HER2 FISH test, which Biocept performs on CTCs, is considered a "gold standard".
Therefore, small size and low number of tumours could potentially account for the high false-negative rate
(38%) seen in this study when accessing NMP22's ability to detect early carcinogenesis or subclinical recurrences.
1) In numerous instances, the literature indicates that radiographs have a high false-negative rate
in detecting cervical-spine fractures.
The false-negative rate
of conventional histology depends on the protocol followed for pathological examination of SLNs which varies considerably throughout Europe  and can be reduced by serial sections and immunohistochemistry (IHC).
Prior researchers have noted a 50% false-negative rate
for the first polysomnograph in diagnosing OSA.