falciparum malaria


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fal·cip·a·rum ma·lar·i·a

malaria caused by Plasmodium falciparum and characterized by malarial paroxysms of severe form that typically occur every 48 hours with acute cerebral, renal, or gastrointestinal manifestations in severe cases, chiefly caused by the large number of red blood cells affected and the tendency for such infected red blood cells to become sticky and clump, thus blocking capillaries.
See also: malarial knobs.

falciparum malaria

[falsip′ərəm]
Etymology: L, falx, sickle, forma, form; It, mal, bad aria, air
the most severe form of malaria, caused by the protozoon Plasmodium falciparum. The condition is characterized by extremely grave systemic symptoms, mild jaundice, mental confusion, enlarged spleen and liver, increased respiratory rate, edema, GI symptoms, and anemia. The parasite replicates so rapidly in erythrocytes that cerebral vessels may be obstructed. Falciparum malaria episodes do not last as long as other forms of malaria; if treatment is begun promptly, the disease may be mild and the recovery uneventful. Relapses are uncommon, but death may result from dehydration and anemia. The usual treatment is chloroquine, but patients known to have contracted malaria in an area that harbors drug-resistant P. falciparum are often treated with a combination of quinine, pyrimethamine, and mefloquine. Compare quartan malaria, tertian malaria. See also algid malaria, blackwater fever, malaria.

fal·cip·a·rum ma·lar·i·a

(fal-sip'ă-rŭm mă-lar'ē-ă)
Disease caused by Plasmodium falciparum and characterized by intense malarial paroxysms that after synchronization occur every 48 hours with acute cerebral, renal, or gastrointestinal manifestations in severe cases, chiefly caused by the large number of red blood cells affected and the tendency for infected red blood cells to become sticky and then clump, thus blocking capillaries.
Synonym(s): malignant tertian malaria.

falciparum malaria

The most dangerous form of MALARIA caused by the parasite Plasmodium falciparum . There is severe breakdown of red blood cells, sometimes with so much release of HAEMOGLOBIN that it appears in the urine (BLACKWATER FEVER). Falciparum malaria also features blockage of small blood vessels by parasite and toxic effects on the linings. The consequent damage to organs, including the brain, is a major danger.
References in periodicals archive ?
Genetic markers associated with dihydroartemisininpiperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype-phenotype association study.
Most of these findings as a predictor of mortality in malarial ARF and in complicated falciparum malaria are consistent with other studies (Mahakur et al 1992, Lalloo DG et al 1996, Prakash J et al 1996, AK Bhattacharya et al 2001, Mehta KS et al 2001, Naqvi R et al 2003 and Koh KH et al 2004).
Risk factors for gametocyte carriage in uncomplicated Falciparum malaria.
60) The phase II study revealed that monthly tafenoquine was safe, well tolerated, and highly effective in preventing P vivax and multidrug-resistant P falciparum malaria in Thai soldiers during 6 months of prophylaxis.
On the other hand, the findings of the study were not consistent with a previous study on the distribution of mefloquine in the blood components of patients with uncomplicated falciparum malaria in Thailand, which reported similar concentrations of mefloquine in the whole blood and plasma.
Efficacy and safety of artemether + lumefantrine, artesunate + sulphamethoxypyrazine-pyrimethamine and artesunate + amodiaquine and sulphadoxine-pyrimethamine + amodiaquine in the treatment of uncomplicated falciparum malaria in Bangui, Central African Republic: A randomized trial.
18) We hypothesize that by administering immunizing doses of sodium dithionite it is possible to induce sickling in humans and protect them against the lethal form of Plasmodium falciparum malaria.
falciparum malaria was confirmed on a thin blood film, with hyperparasitaemia of 13.
Malaria without fever has been reported in cases of Plasmodium falciparum malaria in non-immune people (3).
Since 1994, falciparum malaria on Thailand's western border has been kept in check by an artesunate-mefloquine combination.
A randomized, parallel study of the safety and efficacy of 45 mg primaquine versus 75 mg bulaquine as gametocytocidal agents in adults with blood schizonticide-responsive uncomplicated falciparum malaria [ISCRTN50134587].