margin of safety

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margin

 [mahr´jin]
an edge or border.
gingival margin gum margin.
gum margin the border of the gingiva surrounding, but unattached to, the substance of the teeth.
margin of safety a calculation that takes the highest animal no observed adverse effect level and estimates a maximum safe level of exposure for humans. It is now generally superseded by the reference dose.

mar·gin of safe·ty

the range between the minimal therapeutic dose and the minimal toxic dose of a drug.

margin of safety

an index of a drug's effectiveness and safety. It is calculated as the amount of drug that is lethal to 1% of animals (LD1) divided by the amount of drug that causes a beneficial effect in 99% of the animals (ED99). See also dose-response relationship.

mar·gin of safe·ty

(mahr'jin sāf'tē)
The area between the minimal therapeutic dose and the minimal toxic dose of a drug.
Synonym(s): safety margin.

mar·gin of safe·ty

(mahr'jin sāf'tē)
The gap (i.e., range) between the minimal therapeutic dose of a drug and its minimal toxic dose.
References in periodicals archive ?
As shown in Table 2, the present upper-bound solution yields a factor of safety of 1.
Designing to an acceptable probability of failure is a better engineering practice than setting an arbitrary factor of safety threshold.
In limit equilibrium state, a slope is in critical state if the factor of safety closes to one.
Nonetheless, the variation increased rapidly for higher values of factor of safety.
10 show the results of this study determined on the basis of factor of safety (FOS) computed by the ratio of Cyclic Stress Ratio (CSR) and Cyclic Resistance Ratio (CRR) at different percentages of nes content i.
A Method of Calculation of Total Factor of Safety of Slopes by Elasto-Plastic FEM, Soils and Foundations, 29(2), 1989, pp.
Designers changed the radius in certain areas of the strut and modified the stent thickness, for a considerably higher factor of safety.
The factor of safety (FS) can be obtained by the force equilibrium equation as follows:
After finding the approximate slope angle shown in Table 2 by plotting the values calculated from above formulae on chart 01 and height of slope another design chart for circular failure which includes several factors of safety gave the factor of safety for the used angle of slope and height shown in table 2.
The procedure for determining factor of safety and probability of liquefaction for a soil element in a CPT profile and the probability of ground failure at a site is described in the following.
giving it a factor of safety slightly higher than 10.
0 m long pcc pole of 200 kg working load with factor of safety 2.