margin of safety

(redirected from factor of safety)
Also found in: Dictionary, Thesaurus, Financial, Acronyms, Encyclopedia, Wikipedia.

margin

 [mahr´jin]
an edge or border.
gingival margin gum margin.
gum margin the border of the gingiva surrounding, but unattached to, the substance of the teeth.
margin of safety a calculation that takes the highest animal no observed adverse effect level and estimates a maximum safe level of exposure for humans. It is now generally superseded by the reference dose.

mar·gin of safe·ty

the range between the minimal therapeutic dose and the minimal toxic dose of a drug.

margin of safety

an index of a drug's effectiveness and safety. It is calculated as the amount of drug that is lethal to 1% of animals (LD1) divided by the amount of drug that causes a beneficial effect in 99% of the animals (ED99). See also dose-response relationship.

mar·gin of safe·ty

(mahr'jin sāf'tē)
The area between the minimal therapeutic dose and the minimal toxic dose of a drug.
Synonym(s): safety margin.

mar·gin of safe·ty

(mahr'jin sāf'tē)
The gap (i.e., range) between the minimal therapeutic dose of a drug and its minimal toxic dose.
References in periodicals archive ?
1) through (7), the time-dependent magnitude of factor of safety for the two scenarios immediately and long-term after earthquake occurrence is computed and presented in Figure 1.
Document identifier: KIT 206 Descriptors: Buildings, Structural design, Structural systems, Concretes, Structures, Design, Reinforced concrete, Prestressed concrete, Factor of safety, Durability, Design calculations, Prestressing steels, Structural members, Fire resistance, Construction materials, Safety measures, Approval testing, Serviceability limits, Tendons, Reinforcement, Lightweight aggregates, Aggregates ISBN: 978 0 580 50985 8 Material number: 30232841
As a result, liquefaction potential is evaluated only by the factor of safety.
The procedure for determining factor of safety and probability of liquefaction for a soil element in a CPT profile and the probability of ground failure at a site is described in the following.
4 factor of safety designation means that the first stage tank and the interstage can withstand 140 percent the maximum internal pressure expected during flight, and qualifies both pieces of hardware to meet human rating safety requirements, as defined by NASA.
Material Library Manager improvements such as: -- additional materials in the built-in library -- the capability to exchange material data with third-party material libraries through XML -- a parallel iterative solver that provides faster solution times for linear static stress analysis -- variable surface loads and a new pulley element for MES -- body-to-body radiation for transient heat transfer analysis -- improved convergence and faster solution times for fluid flow analysis -- new result evaluation and presentation capabilities such as: -- realistic visualization of beam and plate elements -- factor of safety and strain energy density contours for linear static stress analysis