Novel oral factor Xa
and thrombin inhibitors in the management of thromboembolism.
The dPT ratio showed a linear increase in relation to increasing anti-Xa values in all samples spiked with factor Xa
inhibitors (1:500 dilution of thromboplastin reagent, danaparoid [Figure 4, A], r = 0.
2] Nonstandard abbreviations: DTI, direct thrombin inhibitor; DFXaI, direct factor Xa
inhibitor; PT, prothrombin time; APTT, activated partial thromboplastin time.
Specifically, it is a measure of the body's inhibition of factor Xa
Major bleeding events occur infrequently in patients taking Factor Xa
inhibitors (1-4% per year in clinical studies) and standard measures are employed to manage these events.
Betrixaban represents an important addition to our late-stage portfolio with the potential to be a significant medicine in the Factor Xa
inhibitor class," said Luciano Rossetti M.
Within two minutes following completion of the 210 mg and 420 mg bolus of andexanet alfa, anti Factor Xa
activity decreased dose-dependently by 20 percent and 53 percent respectively.
The Competitive Intelligence Report Antithrombotics as of May 2007 provides a competitor analysis in the development pipeline of novel anticoagulant and antiplatelet agents directed against targets such as factor IIa (thrombin), factor Xa
, the ADP platelet receptor and PAR-1 /thrombin receptor and other novel targets.
Rivaroxaban is an oral anticoagulant, direct factor Xa
inhibitor, developed by Bayer HealthCare and sold under the trademark Xarelto.
San Francisco / USA, to evaluate the safety of PRT4445, an investigational antidote for Factor Xa
inhibitors, in healthy volunteers who have been administered the oral anticoagulant XareltoA (rivaroxaban).
Rivaroxaban is a novel, oral, once-daily direct Factor Xa
inhibitor in advanced clinical development for a range of patients who could benefit from the prevention and/or treatment of blood clots.
The oral direct Factor Xa
inhibitor proved decrease in risks compared to warfarin in three major results of stroke, major bleeding and all-cause death.