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factor VIII inhibitor |
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factor VIII inhibitor IgG alloantibodies to factor VIIIc that inhibits coagulation, which occur in up to 50% of Pts with severe hemophilia A; factor VIII antibodies may arise spontaneously in inflammatory diseases–eg, SLE, rheumatoid
arthritis, and ulcerative colitis, or with ↑ age, during post-partum period, or in drug reactions Mechanism Factor VIII inhibitor inactivates factor VIII by steric prevention of interaction of factor VIII with vWF, phospholipids, activated
factors IX and X, and thombin, and by proteolysis. See Bethesda units, Factor VIII. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| The PTT partially corrected with the addition of normal plasma, so factor VIII assay was done, which showed decreased activity at 8% with positive titers for factor VIII inhibitor (72 Bethesda, normal, 0. |
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