factor VIII inhibitor

factor VIII inhibitor

IgG alloantibodies to factor VIIIc that inhibits coagulation, which occur in up to 50% of Pts with severe hemophilia A; factor VIII antibodies may arise spontaneously in inflammatory diseases–eg, SLE, rheumatoid arthritis, and ulcerative colitis, or with ↑ age, during post-partum period, or in drug reactions Mechanism Factor VIII inhibitor inactivates factor VIII by steric prevention of interaction of factor VIII with vWF, phospholipids, activated factors IX and X, and thombin, and by proteolysis. See Bethesda units, Factor VIII.
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For more information on factor VIII inhibitor plasmas, visit http://www.
Perform an assay that measures factor VIII inhibitor concentration if the plasma factor VIII level fails to increase as expected, or if bleeding is not controlled with expected dose.
Consequently, up to 30 per cent of these patients develop Factor VIII inhibitor antibodies.
Life-threatening sublingual hematoma in a severely hemophilic patient with factor VIII inhibitor.
Factor VIII inhibitor formation in case 1 occurred 6 months after giving birth; underlying disorders were not identified in cases 2 or 3.
Clinical experience suggests that patients with a Factor VIII inhibitor titer of less than five Bethesda Units (B.
Therefore, the strikingly impaired factor VIII activity was most likely caused by an acquired factor VIII inhibitor.
A diagnosis of acquired hemophilia A with Factor VIII inhibitor secondary to postpartum state was made.
Part 3 Activated prothrombin complex concentrate (coagulation factor VIII inhibitor "bypassing" preparation activity.
To find out more about any of the Factor VIII inhibitor kits or any of the other products available from Affinity Biologicals Inc.