factor V Leiden


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factor V Leiden

(lī'den),
variant of the protein factor V (5), a clotting factor. Factor V Leiden gene is present in 3% of the general population. People who carry the factor V Leiden gene have a fivefold greater risk of thrombosis than the rest of the population. The factor V mutation (factor V Leiden) is the most common genetic cause of venous thrombosis. The factor V Leiden mutation causes resistance to activated protein C, yielding a defect in the natural anticoagulation system.

factor V Leiden

Hematology A variant of factor V present in 3%-8% of Caucasians associated with a ↑ risk of DVT. See LETS, Hereditary thrombophilia.
References in periodicals archive ?
But in August a rare blood clotting disorder, Factor V Leiden, caused a fatal pulmonary embolism, an inquest heard.
However, the patient was positive for the factor V Leiden heterozygous mutation.
Objective: To determine the association of factor V Leiden mutation with recurrent pregnancy loss.
Objective: To determine the frequency of Factor V Leiden in cases of Deep Vein Thrombosis and Healthy controls.
16 June 2014 - US life sciences and clinical diagnostics company Agena Bioscience Inc said Monday that US genetic analysis service provider Sequenom Inc (NASDAQ:SQNM) had obtained US FDA 510(k) premarket approval for the IMPACT Dx Factor V Leiden, Factor II Genotyping Test and the IMPACT Dx System.
Women were not excluded if they were heterozygous for a factor V Leiden mutation.
At that time, he was found to be heterozygous for Factor V Leiden mutation.
Summary: One in five patients diagnosed with blood clots (thrombosis) at Mafraq Hospital carries a genetic protein mutation known as Factor V Leiden.
Factor V Leiden and prothrombin G20210A mutation allele frequencies in Europeans are been reported to be 1.
Thrombotic screen testing revealed a heterozygous factor V Leiden mutation and a bleeding screen type I von Willebrand disease (vWD).