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One of our purposes is to find the dynamic functional connectivity or interaction, in which we need to establish the change point from fMRI data first.
Early fMRI studies primarily focused on changes in the magnitude of the BOLD response, assessing activation and de-activation of brain regions during a task.
Routine fMRI of language in pre-surgical epilepsy patients has been introduced in the Epilepsy Unit at Mediclinic Constantiaberg.
The interpretation of fMRI results is complex and the technique has still not been adopted as a mainstream clinical tool, even in the developed world.
fMRI can also reveal how the disease affects the structure of the brain and help explain how these changes cause the painful sensations that are such a common and debilitating symptom of the disease.
The research will also take forward the findings of a study that involved healthy people being given an fMRI scan and anaesthetised while they listened to researchers talking.
In contrast, fMRI and PET provide information on the changes in blood flow that accompany neuronal activation with relatively high spatial resolution (1 - 10 mm), but with a temporal resolution limited by the rate of the much slower haemodynamic changes that accompany neuronal depolarisation.
When a functional MRI (fMRI) study of the brain is performed, about 30 to 60 images covering the entire 3-D brain are repeated hundreds of times like the frames of a movie but, with fMRI, like a 3-D movie," Feinberg said.
The advantage of fMRI is that it can discern the blood flow changes that indicate changes in brain activity.
fMRI studies have demonstrated the recruitment of additional brain regions to cope with the loss of cerebral function with OSA.