extrinsic pathway


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Related to extrinsic pathway: Prothrombin time, APTT

extrinsic pathway

Hematology The arm of coagulation activation which, like the intrinsic pathway, converges on the common pathway, ie factor X activation; the EP is activated by exposure of blood to tissue factor, circulating factor VII, Ca2+ and phospholipid. Cf Common pathway, Intrinsic pathway.

Extrinsic pathway

One of three pathways in the coagulation cascade.

extrinsic

of external origin.

extrinsic allergic alveolitis
see hypersensitivity pneumonitis.
extrinsic factor
see extrinsic factor.
extrinsic incubation period
the period between infection of the arthropod insect vector and the vector's ability to infect the next vertebrate host.
extrinsic pathway
see coagulation pathways.
extrinsic protein
see membrane proteins.
References in periodicals archive ?
In order to obtain more evidence that the extrinsic pathway was stimulated by the combined treatment with Baccharin and Drupanin, we examined the expression levels of TRAIL and FasL mRNAs at 48 h after the start of the combined treatment (Fig.
4 represents a simplified coagulation cascade incorporating the intrinsic and extrinsic pathways (47).
The extrinsic pathway directly activates the caspase cascade.
SP600125, a selective JNK inhibitor, protects ischemic renal injury via suppressing the extrinsic pathways of apoptosis.
The extrinsic pathway of apoptosis is triggered by external signals that activate cell surface death receptors, including Fas.
Capoxigem affects a number of different oncogenic signaling pathways, including the HIF-1, VEGF, VEGF-R and PDGF systems for angiogenesis; the EGFR, HER2/neu, Bcr/Abl for growth control and differentiation; the intrinsic and extrinsic pathways for apoptosis; and the integrin and metalloproteinase systems for tissue invasion and metastasis.
As an anti-cancer treatment, Capoxigem affects a number of different oncogenic signaling pathways, including the HIF-1, VEGF, VEGF-R and PDGF systems for angiogenesis; the EGFR, HER2/neu, Bcr/Abl for growth control and differentiation; the intrinsic and extrinsic pathways for apoptosis; and the integrin and metalloproteinase systems for tissue invasion and metastasis.
Abnormalities in these pathways leading to oncogenic transformation include the HIF-1, VEGF, VEGF-R and PDGF systems for angiogenesis; the EGFR, HER2/neu, Bcr/Abl for growth control and differentiation; the intrinsic and extrinsic pathways for apoptosis; the integrin and metalloproteinase systems for tissue invasion and metastasis.
Factor Xa is the common point between extrinsic pathways (which initiate the clotting process) and intrinsic pathways (which amplify the clotting process).