extravascular


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Related to extravascular: extravascular fluid

extravascular

 [ek″strah-vas´ku-ler]
situated or occurring outside a vessel or the vessels.

ex·tra·vas·cu·lar

(eks'tră-vas'kyū-lăr),
Outside the blood vessels or lymphatics or of any special blood vessel.

extravascular

(ĕk′strə-văs′kyə-lər)
adj.
1. Located or occurring outside a blood or lymph vessel.
2. Lacking vessels; nonvascular.

hemoglobinuria

Hematology The presence of Hb in the urine which, if of sufficient quantity, colors urine, the intensity of which directly correlates with the quantity of Hb. See Paroxysmal cold hemoglobinuria, Paroxysmal nocturnal hemoglobinuria.
hemolysis Destruction or lysis of RBCs
Hemolysis
Intracorpuscular hemolysis
•  Membrane defects, eg hereditary elliptocytosis, spherocytosis, stomatocytosis and paroxysmal nocturnal hemoglobinuria
•  Metabolic defects, eg G6PD, pyruvate kinase deficiency
•  Abnormal Hbs see Hemoglobin.
Extracorpuscular hemolysis
1º immune reactions, eg autoimmune hemolytic anemia
2º immune reactions, due to
• Infections, eg Bartonella, Clostridia, malaria, sepsis
• Neoplasia, eg lymphoma, leukemias
• Drug reactions due to the 'Innocent bystander' phenomenon (drug-antibody complex activates complement, causing intravascular hemolysis, eg quinidine), hapten-mediated —a protein-bound drug attaches to the red cell membrane, eliciting an immune response when the hapten-protein complex is recognized as foreign, evoking an immune response, eg penicillin acting as a hapten
• Induction of autoimmunity by RBC antigen alterations, eg Rh antigen
Physical, eg thermal, concentrated glycerol due to inadequate washing of frozen blood, bladder irrigation, cardiac valves
Extravascular Less severe, IgG-mediated and does not activate complement, eg Rh, Kell, Duffy Laboratory ↓ haptoglobin, ↓ T1/2 of circulating RBCs, ↑ indirect BR as liver capacity to conjugate BR–ergo direct BR is overwhelmed by massive hemolysis, ↑ LDH, Hb in blood and urine, hemosiderinuria, MetHb and metalbumin, ↑ urobilinogen in urine and feces, ↑ in acid phosphatase, K+, and prostatic acid phosphatase Clin Chem 1992; 38:575; peripheral smears demonstrate anisocytosis, polychromatophilia, nucleated RBCs, basophilic stippling; immune hemolysis is suggested by spherocytes NEJM 2000; 342:722cpc
Intravascular More severe, IgM-mediated and requires complement activation, eg ABO blood groups Laboratory ↑ free Hb  Note: Clinically significant hemolysis is usually detected by hemagglutination, less commonly by hemolysis per se, which detects anti-P,
-P1, -PP1Pk, -Jka, -Lea, occasionally also anti-Leb and -Vel

extravascular

Outside a blood vessel or the circulatory system.

extravascular

situated or occurring outside a vessel or the vessels.
References in periodicals archive ?
IVL continues to present diagnostic challenges due to its elusive and diverse pathologic and clinical findings, and according to Ponzoni and colleagues (9), a comprehensive analysis is needed to find analogies and differences between the intravascular and extravascular components of large B-cell lymphomas to further characterize them and potentially formulate more focused treatment depending on each patient's unique presentation.
In contrast, IgG-coated RBCs are targeted primarily for extravascular destruction.
Vascular endothelium is the main controller of leukocyte traffic between the bloodstream and the extravascular space.
A pure, or primary, form arises within dilated vascular space; a mixed, or secondary, form occurs within a preexisting vascular lesion, such as a hemangioma or pyogenic granuloma; and a rare, extravascular form arises in a hematoma.
Plasma IgG, IgA and IgM are the major serum immunoglobins that protect the extravascular compartment against pathogenic viruses and microorganisms (Li et al.
Limitations of the current study, she said, included not collecting data on body mass index, which may affect blood loss and rates of infection, and the fact that hematocrit levels can be affected by administration of intravenous fluid and extravascular fluid shifts during cesarean delivery.
The increased vascular permeability in anaphylaxis can result in transfer of 50% of intravascular fluid into the extravascular space within 10 minutes.
Using a 1 x 5 [micro]m photometric window, a series of average pixel intensity measurements were made along the vessel wall and in extravascular regions immediately adjacent to the wall.
The particles thus formed have access to extravascular sites and target cell populations and are suitable for the therapeutic delivery of nucleic acids.
Pharmacological actions of eledoisin on extravascular smooth muscle.
A scientific paper presenting the study's findings titled, "Intracranial Tumor Extravascular Extracellular Space: Examining the Correlation Between ADC and DCE MRI Metrics in Human Meningioma," will be presented at RSNA on Tuesday, November 27 at 3:30 p.