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extrarenal |
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Between 55 to 90% of patients who present with renal failure severe enough to require dialysis during the acute phase of the disease will recover enough function to come off dialysis; (47) however, in whom there is no evidence of return of renal function after two to three months of immunosuppressive drug therapy, excessive therapy in the absence of active extrarenal disease should be avoided to minimize treatment-related morbidity and mortality. 1971) and extrarenal mechanisms such as lead effects on porphyrin metabolism (Emmerson and Ravenscroft 1975) have also been considered. Approximately 90% of EPO is synthesized in the renal cortical cells, whereas the remainder is synthesized in extrarenal sites, primarily the liver. |
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