extramammary Paget disease

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ex·tra·mam·ma·ry Pa·get dis·ease

an intraepidermal form of mucinous adenocarcinoma, most commonly in the anogenital region, presenting as erythematous plaques in the elderly, which may be associated with sweat gland or regional visceral carcinoma.
Synonym(s): Paget disease (3)

ex·tra·mam·ma·ry Pag·et dis·ease

(EMPD) (eks'tră-mam'ăr-ē pa'jĕt di-zēz')
An intraepidermal form of mucinous adenocarcinoma, most commonly in the anogenital region.
Synonym(s): Paget disease (3) .

extramammary Paget disease

A plaque with a definite margin found in the anogenital area and in the axilla. It is a rare malignant disease and is treated by surgical excision.


Sir James, English surgeon, 1814-1899.
extramammary Paget disease - Synonym(s): Paget disease
Paget abscess syndrome - an abscess recurrence at the same site after apparent cure.
Paget associated osteogenic sarcoma
Paget cells - relatively large neoplastic epithelial cells.
Paget disease - an intraepidermal form of mucinous adenocarcinoma, most commonly in the anogenital region. Synonym(s): extramammary Paget disease
Paget disease of bone - osteitis deformans. Synonym(s): Paget II syndrome
Paget disease of the nipple - ductal carcinoma.
Paget disease of the penis - carcinoma that develops after balanitis.
Paget juvenile syndrome - Synonym(s): familial osteoectasia
Paget quiet necrosis - necrosis in the superficial layers of the shaft of a long bone.
Paget I syndrome - relationship to or possible extension of mammary duct carcinoma.
Paget II syndrome - Synonym(s): Paget disease of bone
Paget test - to determine whether a mass is a solid tumor or a cyst.
Paget-von Schrötter syndrome - stress thrombosis or spontaneous thrombosis of the subclavian or axillary vein. Synonym(s): effort-induced thrombosis
References in periodicals archive ?
Extramammary Paget disease was primary and limited to the epidermis in 7 of the patients, (8,13,14-17) (also current report).
The lesions of extramammary Paget disease were located in the suprapubic region, pubic area, groin, buttocks, thighs and perineum--including the penile shaft and urethral meatus, the scrotum, and the vulva.
Lesions of extramammary Paget disease usually appeared as patches of macular erythema, (14,16) an "erythematous eruption", (13) or erythematous papules and plaques, (8,15,16) current report.
Complete healing, without recurrence, of the cutaneous extramammary Paget disease was noted in seven patients whose disease was treated with topical imiquimod 5% cream: three patients with previously untreated extramammary Paget disease (6,13) (also current report) and four patients whose disease was recurrent following various initial treatments such as aminolevulinic acid photodynamic therapy, (14) electrodes-iccation and curettage, (8) surgical excision using the Mohs micrographic technique, (9-12) and wide surgical excision.
A partial response to imiquimod after topical treatment of extramammary Paget disease was observed in two patients.
20,21) However, the current availability of the topical immunomodulator imiquimod presents the option for an alternative approach to the management of extramammary Paget disease.
Based on our review of the currently published reports of extramammary Paget disease patients whose disease has been successfully treated with imiquimod cream, we suggest that topical application of imiquimod may be considered as an initial treatment of primary cutaneous extramammary Paget disease.
Extramammary Paget disease has successfully been treated with topical imiquimod.
Cutaneous lesions of extramammary Paget disease can mimic other conditions such as chronic candidal intertrigo, dermatitis (contact, irritant, or seborrheic), dermatophyte-related tinea cruris, psoriasis vulgaris (inverse), and squamous cell carcinoma in situ (Bowen disease).