extrahepatic cholestasis

extrahepatic cholestasis

cholestasis occurring outside the liver, caused by blockage of a bile duct or ducts. It may be caused by a tumor or stricture, a gallstone or other damage in the duct, pancreatitis, or other causes.
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Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.
For FT-AT failure, these risk factors were hemolysis, inflammation (confirmed sepsis, a sedimentation rate >20 mm, C-reactive protein >5 mg/ L), possible Gilbert syndrome (total bilirubin concentration >17 [micro]mol/L, including >50% nonconjugated bilirubin), acute hepatitis, drugs inducing cholestasis or an increase in transaminases, and extrahepatic cholestasis.
2]-macroglobulin >3 g/L, possible Gilbert syndrome, or increased bilirubin or GGT with extrahepatic cholestasis.
Application of keratin immunocytochemistry and sirius red staining in evaluating intrahepatic changes with acute extrahepatic cholestasis due to hepatic duct carcinoma.
Higher levels suggest that extrahepatic cholestasis is an unlikely diagnosis.
An increase in urinary bilirubin is nearly always indicative of a corresponding increase in the serum direct fraction attributable to intrahepatic or extrahepatic cholestasis.
The greatest increases are observed in acute viral hepatitis or extrahepatic cholestasis [77].

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