Our findings indicate that both 6-HITC and SFN activate Nrf2, resulting in up-regulation of GCL and the GSTs and MRPs responsible for conjugation of MeHg with GSH and excretion of the MeHg-GSH adduct into the extracellular space.
A reduction of steady-state levels of MeHg in cells is associated with diminished chemical modification of cellular proteins, confirming the importance of formation of the MeHg-GSH adduct, and its excretion into the extracellular space, in the detoxification of MeHg.
The virus particles seen in the extracellular space
were apparently released prior to heat treatment of the tumors (Fig.
In these studies, phase angle indicates cell membrane potential and water distribution between the intra- and extracellular spaces
and is used widely in human medicine as a means to measure nutritional status, but it has never been applied to fish or lower vertebrates.
Microdialysis is a highly valuable sampling tool that can be used in vivo to measure free, unbound analyte concentrations located in interstitial and extracellular spaces
People with cystic fibrosis have a defective or missing version of a protein responsible for, among other things, releasing glutathione into the extracellular spaces
A key difference between direct injection and PMED delivery is the efficiency with which this is done: Direct injection delivers the DNA to extracellular spaces
and relies on an inefficient, non-specific uptake of the DNA by neighboring cells or transport along lymphatic vessels to draining lymph nodes.
While engineering megakaryocytes and platelets for infusion into their mouse models of Hurler, the scientists report they were able to release IDUA directly into amply sized extracellular spaces
or inside micro-particles as the cells matured or activated.
She had suffered cerebral oedema, a condition characterised by excess accumulation of water in the intracellular or extracellular spaces
of the brain.
Sphingolipids are found in the extracellular spaces
of the stratum corneum, where they play a critical role in strengthening the barrier function of the skin, promoting moisture retention and increasing elasticity of the skin, according to the company.
The major pathological mechanism underlying ischemic/ reperfusion injury to brain tissue is a phenomenon known as 'excitotoxicity' in which excessive release of glutamate (which builds up in the extracellular spaces
after stroke onset) causes an inappropriate activation of ionotropic N-methyl-d-aspartate (NMDA) receptors in the brain.