MAPK1

(redirected from extracellular signal-regulated kinase 2)
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MAPK1

A gene on chromosome 22q11.2|22q11.21 that encodes a protein of the MAP kinase family. MAP kinases (e.g., extracellular signal-regulated kinases) integrate multiple biochemical signals, and are involved in cell proliferation, differentiation, transcription, regulation and development. Once MAPK1 is activated by phosphorylation by an upstream kinase, it translocates to the nucleus of the stimulated cell, where it phosphorylates target molecules.
References in periodicals archive ?
In a recent paper published in the Journal of Clinical Investigation, MAP kinase (also known as ERK2, extracellular signal-regulated kinase 2, the subject of the UT Southwestern-Regeneron patent) was shown to be hyperexpressed and hyperactivated in breast cancer.

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