extended-spectrum beta-lactamase


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extended-spectrum beta-lactamase

Third generation cephalosporinase Microbiology A beta-lactamase produced by gram-negative enteric bacteria, in particular K pneumoniae and E coli, which are resistant to third-generation cephalosporins. See Third-generation cephalosporin.

extended-spectrum beta-lactamase

Abbreviation: ESBL
Any enzyme that makes bacteria (esp. gram-negative bacteria such as the Enterobacteriaceae) resistant to the effects of broad-spectrum beta-lactam antibiotics.
See also: beta-lactamase
References in periodicals archive ?
Epidemiology of extended-spectrum beta-lactamases in Brazil: clinical impact and implications for agribusiness.
Detection of extended-spectrum beta-lactamases among Enterobacteriaceae by use of semiautomated microbiology systems and manual detection procedures.
Extended-spectrum beta-lactamases in enterobacteriaceae in Buenos Aires, Argentina, public hospitals Antimicrob Agents Chemother 47 (9): 2864-2867.
extended-spectrum beta-lactamase (ES[beta]L) production by Gram-negative bacilli
1 The most important and common cause of resistance to beta- lactam antibiotics preferred to treat these infections is the production of beta-lactamase and especially extended-spectrum beta-lactamase (ESBL).
Boronic acid disk tests for identification of extended-spectrum beta-lactamase production in clinical isolates of Enterobacteriaceae producing chromosomal AmpC beta-lactamases.

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