In healthy humans, urinary exosome
analysis has identified over 1000 proteins from different segments of the nephron, but, most importantly, 34 of them were implicated in many kidney diseases such as autosomal dominant polycystic kidney disease type 1 (polycystin-1), autosomal dominant and recessive nephrogenic diabetes (aquaporin-2), antenatal Bartter syndrome type 1 (Na-K-2Cl symport), and Gitelman's syndrome (thiazide-sensitive Na-Cl cotransporter) (45).
Andrew Maniotis, Division Head of the Cancer Biology Program at BRS explained the new exosome
technology developed at BRS, “we developed a new process to enrich and collect exosomes
from stem cells of various tissues, including the gut's immune system that should prove to be very therapeutic for a number of indications.
The team, based at the Cancer Research Wales laboratories in the grounds of the Velindre Cancer Centre, in Cardiff, have discovered that prostate tumours are capable of releasing microscopic particles - known as exosomes
- which causes some of the immune suppression.
Diagnostics is developing several tests using the non-invasive exosome
technology to measure single genetic mutations such as those found in the EGFR, KRAS and BRAF genes for use in lung, colon, brain and melanoma cancers.
com/research/jv4bkz/micrornas_and) has announced the addition of the "MicroRNAs and Exosomes
Market Report 2012" report to their offering.
We look forward to helping Codiak grow to become a dominant force in the field of exosome
biology and to working with the founders, Doug Williams and MD Anderson to ensure that Codiak's developments provide meaningful advancements in the fight against cancer and other diseases.
, they analyzed the research trends, types of downstream applications being performed as well as biomarker classes being studied currently and this is the First Market Report to Document the Market Landscape of Exosomes
In 1996, a Dutch group led by Graca Raposo of Utrecht University in the Netherlands reignited the exosome
field by reporting that the vesicles are also made by immune cells called B lymphocytes.
Despite this, little is known about the mechanism and molecular players involved in exosome
biogenesis and secretion.
Potential Market Opportunity SizesCompanies Mentioned - AdnaGen (now Qiagen) - Agena Bioscience - Angle plc - ApoCell - Biocept - BioFluidica - Bio-Rad Laboratories - Boreal Genomics - Chronix Biomedical - Clearbridge BioMedics - Cynvenio - Cytolumina Technologies Corp - CytoTrack - Diagnologix LLC - Epic Sciences - Exosome
Diagnostics - Exosome
Sciences - Fluidigm Corp - Fluxion Biosciences - Genomic Health - Guardant Health - HansaBiomed - Horizon Discovery - iCellate - Illumina - Inivata - Janssen Diagnostics - Molecular MD - Myriad Genetics - Natera - New Oncology - Personal Genome Diagnostics - RainDance Technologies - Rarecells SAS - Silicon Biosystems - SRI International - Sysmex Inostics - Trovagene For more information visit http://www.
Their majority owned subsidiary Exosome
Our assay combines two innovative approaches - newly discovered changes in exosome
composition in cancer and probes for measuring altered levels of several protein kinases in exosomes
originating from the cancer tissue.