exosome


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exosome

(ĕk′sō-sōm′)
n.
1. A tiny vesicle created and released from the plasma membrane of various types of cells, especially immune cells, and capable of inducing antigen-specific immune responses.
2. A cellular protein complex containing enzymes that degrade nuclear and cytoplasmic RNA.

exosome

(ĕks′ō-sōm″) [″ + Gr. soma, body]
An intracellular complex that degrades and processes messenger RNA molecules.

exosome

a protein complex containing NUCLEASES involved in degrading mRNA in eukaryotes.
References in periodicals archive ?
In healthy humans, urinary exosome analysis has identified over 1000 proteins from different segments of the nephron, but, most importantly, 34 of them were implicated in many kidney diseases such as autosomal dominant polycystic kidney disease type 1 (polycystin-1), autosomal dominant and recessive nephrogenic diabetes (aquaporin-2), antenatal Bartter syndrome type 1 (Na-K-2Cl symport), and Gitelman's syndrome (thiazide-sensitive Na-Cl cotransporter) (45).
Andrew Maniotis, Division Head of the Cancer Biology Program at BRS explained the new exosome technology developed at BRS, “we developed a new process to enrich and collect exosomes from stem cells of various tissues, including the gut's immune system that should prove to be very therapeutic for a number of indications.
The team, based at the Cancer Research Wales laboratories in the grounds of the Velindre Cancer Centre, in Cardiff, have discovered that prostate tumours are capable of releasing microscopic particles - known as exosomes - which causes some of the immune suppression.
Exosome Diagnostics is developing several tests using the non-invasive exosome technology to measure single genetic mutations such as those found in the EGFR, KRAS and BRAF genes for use in lung, colon, brain and melanoma cancers.
com/research/jv4bkz/micrornas_and) has announced the addition of the "MicroRNAs and Exosomes Market Report 2012" report to their offering.
We look forward to helping Codiak grow to become a dominant force in the field of exosome biology and to working with the founders, Doug Williams and MD Anderson to ensure that Codiak's developments provide meaningful advancements in the fight against cancer and other diseases.
For exosomes, they analyzed the research trends, types of downstream applications being performed as well as biomarker classes being studied currently and this is the First Market Report to Document the Market Landscape of Exosomes.
In 1996, a Dutch group led by Graca Raposo of Utrecht University in the Netherlands reignited the exosome field by reporting that the vesicles are also made by immune cells called B lymphocytes.
Despite this, little is known about the mechanism and molecular players involved in exosome biogenesis and secretion.
Potential Market Opportunity SizesCompanies Mentioned - AdnaGen (now Qiagen) - Agena Bioscience - Angle plc - ApoCell - Biocept - BioFluidica - Bio-Rad Laboratories - Boreal Genomics - Chronix Biomedical - Clearbridge BioMedics - Cynvenio - Cytolumina Technologies Corp - CytoTrack - Diagnologix LLC - Epic Sciences - Exosome Diagnostics - Exosome Sciences - Fluidigm Corp - Fluxion Biosciences - Genomic Health - Guardant Health - HansaBiomed - Horizon Discovery - iCellate - Illumina - Inivata - Janssen Diagnostics - Molecular MD - Myriad Genetics - Natera - New Oncology - Personal Genome Diagnostics - RainDance Technologies - Rarecells SAS - Silicon Biosystems - SRI International - Sysmex Inostics - Trovagene For more information visit http://www.
Their majority owned subsidiary Exosome Sciences, Inc.
Our assay combines two innovative approaches - newly discovered changes in exosome composition in cancer and probes for measuring altered levels of several protein kinases in exosomes originating from the cancer tissue.