exorphin

exorphin

(eks-ōr'fin),
Food-derived opioid peptide, found in wheat gluten.
References in periodicals archive ?
16) BCM-7 can also be hydrolyzed further to produce the shorter exorphin with greater opioid receptor binding affinity, beta-casomorphin-5 (BCM-5).
One hypothesis to explain how gluten can cause behavioral changes (gluten is also implicated in attention deficit, hyperactivity, and autism) is what I call the Exorphin Dysfunction Hypothesis.
Further lending credence to the exorphin dysfunction hypothesis are studies using "mixed agonist/antagonists" drugs (e.
For example, wheat and dairy products contain exorphins (they're like endorphins but not made in the body), which bind to opiate receptors in the brain and produce a euphoric, even drug-like haze.
These criteria include the following: a) many of the foods that "cause trouble in children are weak inhibitors of the conversion of EFAs to prostaglandins (PGs)"; b) boys are affected to a greater degree than girls and "males are known to have much higher requirements for EFAs than females"; c) abnormal thirst is one of the cardinal signs of EFA deficiency; many children suffer with this symptom; d) "many children have eczema, allergies and asthma", all of which can benefit, or be alleviated by EFA supplementation; e) many children are zinc deficient, and zinc is required for conversion of EFAs to PGs; and f) allergies affect many children, especially wheat and milk, "which are known to give rise to exorphins in the gut," which in turn may block conversion of EFAs to PGEI.
In addition, casein, a milk protein concentrated in cheese, also contains a source of opiate-like compounds called exorphins.
These potent endorphins and exorphins give us pleasurable, comforting sensations we can get hooked on.
Exorphins are morphinelike molecules derived from incomplete digestive breakdown of the common food allergens dairy and grain.
Table 5: Increased Intestinal Permeability Conditions Associated Antigens/Agents Associated Coeliac Enteropathy Gluten Crohn's Disease Other IBD Casein & dairy exorphins Alcohol consumption Varies with individual Drug Effects Alcohol Autoimmune Syndromes (?
Many investigators have reported behavioral improvements with avoidance of dietary gluten and casein, presumably by lowering exposure to exorphins.
He noted that alterations of gut barrier function are common and well-documented in these children and that the absorption of exorphins from incompletely digested casein and gluten may significantly contribute to the neurological manifestations of autism.