exopeptidase


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exopeptidase

 [ek″so-pep´tĭ-dās]
a proteolytic enzyme whose action is limited to terminal peptide linkages.

ex·o·pep·ti·dase

(ek'sō-pep'ti-dās),
An enzyme that catalyzes the hydrolysis of the terminal amino acid of a peptide chain; for example, carboxypeptidase. Compare: endopeptidase.

exopeptidase

/exo·pep·ti·dase/ (-pep´tĭ-dās) any peptidase that catalyzes the cleavage of the terminal or penultimate peptide bond, releasing a single amino acid or dipeptide from the peptide chain.

exopeptidase

(ĕk′sō-pĕp′tĭ-dās′, -dāz′)
n.
Any of a group of enzymes that catalyze the hydrolysis of single amino acids from the end of a polypeptide chain.

ex·o·pep·ti·dase

(eks'ō-pep'ti-dās)
An enzyme that catalyzes the hydrolysis of the terminal amino acid of a peptide chain (e.g., carboxypeptidase).
Compare: endopeptidase

exopeptidase

An enzyme that acts to split off AMINO ACIDS or sometimes dipeptides from the ends of a protein molecule.

exopeptidase

a type of protein-splitting ENZYME that hydrolyses the terminal PEPTIDE BONDS rather than those bonds within the chain. There are three main types of exopeptidase in the mammalian gut, each attacking a particular area of the protein: carboxypeptidase attacks the carboxyl end of the chain; aminopeptidase attacks the amino end of the chain; dipeptidase breaks the bond between DIPEPTIDES. Such enzymes complete the digestion of protein prior to absorption into the blood stream. Compare ENDOPEPTIDASE.

exopeptidase

a proteolytic enzyme whose action is limited to terminal peptide linkages.
References in periodicals archive ?
Heterogeneity is observed for many components because of exopeptidase action on the peptide chain, sequence variations, and variable modifications of free sulfhydryl groups of unpaired cysteines (19, 20, 28, 65-67).
In the herbivorous Colorado potato beetle, the food protein hydrolysis is achieved by the initial participation of an aspartic peptidase, followed by serine, cysteine peptidases and later by exopeptidases (Brunelle et al.
No caso da pancreatina, este resultado poderia ser explicado pelo fato de que trata-se de um complexo enzimatico que apresenta tanto endopeptidases (tripsina, quimiotripsina) como exopeptidases (carboxipeptidase A e B) sendo, portanto, capaz de hidrolisar ligacoes peptidicas tanto no interior quanto nas porcoes Nou C- terminais da cadeia peptidica.
Proteinase inhibitors disable endo- and exopeptidases, thus interfering with the digestion processes of many herbivores.
Pronase is a mixture of endo and exopeptidases that is used to completely degrade peptides, making it a great candidate for this application.
The exopeptidases showed peaks in the midgut gland during intermolt.
The exopeptidases act on short chain peptides that are produced by the action of endopeptidases, thus acting as polymer terminal enzymes as part of a cascade effect in protien catabolism.
Peptides generated ex vivo from serum proteins by tumour-specific exopeptidases are not useful biomarkers in ovarian cancer.
In contrast, some advocates of LMWF profiling, having observed similar findings in their own hands, invoked the presence of tumor-specific exopeptidases to account for the apparent specificity of ex vivo-dependent disease patterns and, in a welcome break from the field in general, have taken the appropriate steps toward establishing a rigorous assay platform to carry this effort forward (7).
It was hypothesized that these are derived ex vivo during clotting, representing surrogate markers generated by alterations in serum concentrations or activities of the tumor-derived exopeptidases.
These patterns originate from proteolytic processing of high-abundant proteins ex vivo by a multitude of proteases that include endopeptidases and exopeptidases (14).