exopeptidase


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exopeptidase

 [ek″so-pep´tĭ-dās]
a proteolytic enzyme whose action is limited to terminal peptide linkages.

ex·o·pep·ti·dase

(ek'sō-pep'ti-dās),
An enzyme that catalyzes the hydrolysis of the terminal amino acid of a peptide chain; for example, carboxypeptidase. Compare: endopeptidase.

exopeptidase

/exo·pep·ti·dase/ (-pep´tĭ-dās) any peptidase that catalyzes the cleavage of the terminal or penultimate peptide bond, releasing a single amino acid or dipeptide from the peptide chain.

exopeptidase

(ĕk′sō-pĕp′tĭ-dās′, -dāz′)
n.
Any of a group of enzymes that catalyze the hydrolysis of single amino acids from the end of a polypeptide chain.

ex·o·pep·ti·dase

(eks'ō-pep'ti-dās)
An enzyme that catalyzes the hydrolysis of the terminal amino acid of a peptide chain (e.g., carboxypeptidase).
Compare: endopeptidase

exopeptidase

An enzyme that acts to split off AMINO ACIDS or sometimes dipeptides from the ends of a protein molecule.

exopeptidase

a type of protein-splitting ENZYME that hydrolyses the terminal PEPTIDE BONDS rather than those bonds within the chain. There are three main types of exopeptidase in the mammalian gut, each attacking a particular area of the protein: carboxypeptidase attacks the carboxyl end of the chain; aminopeptidase attacks the amino end of the chain; dipeptidase breaks the bond between DIPEPTIDES. Such enzymes complete the digestion of protein prior to absorption into the blood stream. Compare ENDOPEPTIDASE.

exopeptidase

a proteolytic enzyme whose action is limited to terminal peptide linkages.
References in periodicals archive ?
Heterogeneity is observed for many components because of exopeptidase action on the peptide chain, sequence variations, and variable modifications of free sulfhydryl groups of unpaired cysteines (19, 20, 28, 65-67).
Because of its exopeptidase activity, it has been implicated in the metabolism of metenkephalin (18) and angiotensin (Ang) III (17); its endopeptidase activity is also thought to be involved in neurotensin metabolism (19).
The exopeptidases showed peaks in the midgut gland during intermolt.
Pronase is a mixture of endo and exopeptidases that is used to completely degrade peptides, making it a great candidate for this application.
By contrast, Flavourzyme is a package of enzymes that includes both endoproteases and exopeptidases, which will cut bonds at the ends of the chain as well," said Klaus Pommer, Novo Nordisk BioChem of North America's senior application scientist for Flavourzyme.
Peptides generated ex vivo from serum proteins by tumour-specific exopeptidases are not useful biomarkers in ovarian cancer.
In contrast, some advocates of LMWF profiling, having observed similar findings in their own hands, invoked the presence of tumor-specific exopeptidases to account for the apparent specificity of ex vivo-dependent disease patterns and, in a welcome break from the field in general, have taken the appropriate steps toward establishing a rigorous assay platform to carry this effort forward (7).
It was hypothesized that these are derived ex vivo during clotting, representing surrogate markers generated by alterations in serum concentrations or activities of the tumor-derived exopeptidases.
These patterns originate from proteolytic processing of high-abundant proteins ex vivo by a multitude of proteases that include endopeptidases and exopeptidases (14).