exonucleases


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exonucleases

Enzymes that break down DNA and RNA molecules, starting at the ends of the molecular chains. Exonucleases split off nucleotides one at a time from the end of a chain and may be specific for either end.
References in periodicals archive ?
In addition, the pharmacokinetic behavior of the phosphorothioate nucleotides is generally consistent across species and shows an initial rapid clearance from the plasma due to tissue distribution and (to a lesser extent) exonuclease action (3).
The article shows that co-expressing the Cellectis CCR5 nuclease with an exonuclease -enzyme that is able to modify DNA strands' ends- in blood stem cells achieved a markedly enhanced rate of gene disruption: nearly 50% of treated cells exhibited mutations at the CCR5 target site.
Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repair.