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exonuclease

   Also found in: Dictionary/thesaurus, Wikipedia 0.05 sec.
exonuclease /exo·nu·cle·ase/ (ek?so-noo´kle-as) any nuclease specifically catalyzing the hydrolysis of terminal bonds of deoxyribonucleotide or ribonucleotide chains, releasing mononucleotides.
ex·o·nu·cle·ase (ks-nkl-s, -z)
n.
Any of a group of enzymes that catalyze the hydrolysis of single nucleotides from the end of a DNA or RNA chain.
exonuclease
a nuclease that cleaves single mononucleotides from the end of a polynucleotide chain.
exonuclease III
one from E. coli that removes nucleotides from the 3' ends of double-stranded DNA.
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The probe, which contains both a fluorescence reporter dye at the 5'-end (6-carboxyfluorescein, 6-FAM: maximum emission wavelength = 518 nm) and a quencher dye at the 3'-end (6-carboxytetramethyl rhodamine, TAMRA: maximum emission wavelength = 582 nm), is degraded by the 5'-3' exonuclease activity of the Taq DNA polymerase, and the resulting fluorescence is detected by a laser in the sequence detector (TaqMan ABI Prism 7700 Sequence Detector System; PerkinElmer).
Discrimination of vanadium from zinc using gene profiling in human ... by Huang, Yuh-Chin T. / Environmental Health Perspectives
129 BEESE LS,EMBO J,vol 0010,page 0025,1991,cites= 59,STRUCTURAL BASIS FOR THE 3$-5$ EXONUCLEASE ACTIVITY OF ESCHERICHIA-COLI DNA-POLYMERASE-I - A 2 METAL-ION MECHANISM
A Passage Through Science: Crossing Disciplinary Boundaries by SMALL, HENRY / Library Trends
From the structure of one such enzyme, which they describe in the March 23 Nature, these researchers conclude that an exonuclease may recognize a nucleotide that needs pruning by flipping out the "orphan" base--the one opposite the damaged site--and binding to that.
DNA flips out! Enzymes repair and modify DNA in a surprising way by Travis, John / Science News
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