exon


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ex·on

(ek'son),
A portion of DNA that codes for a section of the mature messenger RNA obtained from that DNA, and is therefore expressed ("translated" into protein) at the ribosome.
[ex- + on]

exon

/ex·on/ (ek´son) the coding region in a gene.

exon

(ĕk′sŏn)
n.
A nucleotide sequence that is found in a gene, codes information for protein synthesis, and is transcribed to messenger RNA.

ex·on′ic adj.

exon

[ek′son]
Etymology: Gk, exo + genein, to produce
the part of a DNA molecule that contains the code for the final messenger RNA. Compare intron.

ex·on

(ek'son)
A portion of a DNA that codes for a section of the mature messenger RNA from that DNA, and is therefore expressed ("translated" into protein) at the ribosome.
[ex- + on]

exon

The segment of deoxyribonucleic acid (DNA) in a gene that codes for some part of the messenger ribonucleic acid (RNA). Any segment that is represented in the RNA product. Segments that do not code for RNA are called introns.

exon

or

extron

(‘ex'for expressed) or - the DNA segments of an INTERRUPTED split gene that are transcribed into RNA and then into the gene product. Exons occur along the length of the gene, and are separated by segments called INTRONS whose sequences are also transcribed into RNA. The intron RNA segments are then excised, leaving behind the exon RNA segments that join up to form a functional RNA molecule, a process called RNA SPLICING.

exon

regions of a primary RNA transcript in eukaryotic cells that are coding and are joined together when introns are spliced-out, to make the functional mRNA.
References in periodicals archive ?
In preclinical results to be presented by Blueprint Medicines at ASH, BLU-285 showed potent inhibition of KIT activity in an AML cell line with the N822K mutation in Exon 17, including reduced phosphorylation, downstream signaling and cellular proliferation.
Contiguous exon deletion or duplication results, as well as complex rearrangements were considered true findings and were not pursued further.
Concerning the KRAS exon 2 assay, 4 of 5 homozygous mutations (G12C, G12S, G12V, G13C; Figure 1, A, and data not shown) could be differentiated from wild type.
1113T>C mutation at exon 8 have been found to be higher than those of diabetic obese with other polymorphisms.
Butcher CM, Hahn U, To LB, Gecz J, Wilkins EJ, Scott HS, Bardy PG, D'Andrea RJ: Two novel JAK-2 exon 12 mutations in JAK2V617F-negative polycythemia vera patients.
A heterozygous deletion of exon 2 was detected in a single black CF patient, using both MLPA and semi-quantitative fluorescent PCR.
However, detection of mutations is difficult because of the large size of the COL4A3 and COL4A4 genes, the need for direct sequencings of exons to maximize mutation detection, the need to detect splicing mutations, and the large number of polymorphisms that exist in these two genes.
For this, they used an AAV (Adeno Associated Virus) vector to insert an appropriate molecule into the cell in order that the defective exon (in the mouse, exon 23) was ignored at splicing.
5 has been greatly extended and enhanced to support the new Agilent exon array platform.
BLU-285 in GIST BLU-285 is a highly targeted drug that potently and selectively inhibits PDGFR[eth] D842V and KIT Exon 17 mutants, which are receptor tyrosine kinase mutants known to be key drivers in treatment-resistant and metastatic GIST.
In this new analysis, 430 (65% of 666 patients) patient tumor samples with wild-type KRAS (exon 2) status were assessed for additional RAS mutations (defined as mutations in exons 3 or 4 of KRAS and/or exons 2, 3 or 4 of NRAS).
To sequence the ligand-binding domain in exon 26 and 29 of the APOB gene (RefSeq NM_000384.