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exencephaly |
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exencephaly [ek′sənsef′əlē] Etymology: L, ex, out + Gk, enkephalos, brain a developmental anomaly characterized by lack of all or part of the skull, so that the brain is exposed. exencephaly a congenital defect in which the brain is completely exposed or protrudes through a defect in the cranial vault. |
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| The supposed actin dependency of anterior but not posterior neuropore closure in mouse embryos (Ybot-Gonzalez and Copp 1999) could thus explain why exencephaly is the dominant NTD observed in VPA-exposed mice (Nau et al. 99-106) reported on the finding that a seven-week-old aborted embryo presented infoldings of the hemispheric neuroepithelium, cranioschisis, exencephaly and excessive vascularity with endothelial proliferation --in short, severe malformation of the brain. |
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