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excitotoxicity |
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excitotoxicity exaggerated and continuous stimulation by a neurotransmitter, especially in those neuronal systems which use glutamate as the transmitter. excitotoxicity Neurology Neuronal injury caused by excessive release of excitatory neurotransmitters–glutamate and aspartate causing damage to nerve and glial cells, which occurs in diverse neurologic diseases that may be acute–eg hypoglycemia, seizures, stroke, or trauma or chronic neurodegenerative disease–eg AIDS-dementia complex, amyotrophic lateral sclerosis, Huntington's disease, and possibly Alzheimer's disease How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Lau hypothesizes that ingestion of the well-established neurotoxicants aspartic acid and L-glutamic acid as additives could lead to a high enough body burden to kill neurons by a mechanism called excitotoxicity. Dubner and Ruda (53) suggested that, in the event of prolonged hyperexcitability and hyperalgesia, a pathological state may develop involving excitotoxicity, cellular dysfunction, and loss of descending control mechanisms. Viral-induced spinal motor neuron death is non-cellautonomous and involves glutamate excitotoxicity. |
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excitotoxicity
