For example, the development of pain-like behaviors following excitotoxic
spinal injury in male rats of three different strains and ovariectomized female rats is related to the rostrocaudal spread of a specific pattern of neuronal loss in the dorsal horn .
The cause of ALS is unknown, but there is evidence that excitotoxic
damage to the motor neurons may play an important role in the disease pathogenesis (Choi, 1992; Rothstein, 1995; Shaw, 1994).
2+] and Na+, with subsequent lethal and sublethal excitotoxic
effects (1, 2, 4).
The dominant PCB components of our complex contaminant formulation are similar to those in the human milk formulation, Accordingly, this PCB formulation lacks effect early in neurodevelopment (prior to synaptogenesis) on N-methyl-D-aspartate receptors, specifically their density, which mediate the excitotoxic
effect of domoic acid in the region of the brain where domoic acid seizures originate.
Wogonin inhibits excitotoxic
and oxidative neuronal damage in primary cultured rat cortical cells.
Mechanisms of cell death induced by the mitochondrial toxin 3-nitro-propionic acid: Acute excitotoxic
necrosis and delayed apoptosis.
10,14,39,45,54] It is posited that excitotoxic
imbalances of cholinergic neurons contribute to memory deficits after TBI, because increases in the amount of AcH in the brain and CSF of humans after TBI are well known.
PQQ's powerful redox cycling abilities help it to chemically modify receptors for the most potent excitotoxic
neurotransmitter, known as NMDA (N-Methyl-D-aspartic acid).
Neurochemical and histochemical characterization of striatal excitotoxic
lesions produced by the mitochondrial toxin 3-nitropropionic acid.
Paraquat induces long-lasting dopamine overflow through the excitotoxic
pathway in the striatum of freely moving rats.
These data support the importance of an excitotoxic
process that is linked to acute posttraumatic cell swelling and amplification of [Ca.
Excitatory neurosteroids attenuate apoptotic and excitotoxic
cell death in primary cortical neurons.