excitatory postsynaptic potential


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ex·cit·a·to·ry post·syn·ap·tic po·ten·tial (EPSP),

the change in potential that is produced in the membrane of the next neuron when an impulse that has an excitatory influence arrives at the synapse; it is a local change in the direction of depolarization; summation of these potentials can lead to discharge of an impulse by the neuron.

ex·cit·a·to·ry post·syn·ap·tic po·ten·tial

(ek-sī'tă-tōr-ē pōst'si-nap'tik pŏ-ten'shăl)
The change in potential that is produced in the membrane of the next neuron when an impulse that has an excitatory influence arrives at the synapse; it is a local change in the direction of depolarization; summation of these potentials can lead to discharge of an impulse by the neuron.

excitatory postsynaptic potential (EPSP)

a reduction in the RESTING POTENTIAL of a postsynaptic cell caused by the arrival of TRANSMITTER SUBSTANCE from the presynaptic cell. The reduction takes the membrane potential close to the THRESHOLD and, therefore, nearer to itself forming an ACTION POTENTIAL. see FACILITATION.
References in periodicals archive ?
The nAChR responds to neurotransmitter stimulation by allowing rapid influx of sodium, producing an excitatory postsynaptic potential.
This causes the excitatory postsynaptic potential to stimulate either QA or KA receptors, which in turn activate additional NMDA receptor sites, thereby enhancing the excitatory potential of the initial signal.
Keywords: Centella asiatica Asiatic acid Acetylcholinesterase Excitatory postsynaptic potential Locomotor activity
After stability of the recording had been obtained [recording for at least 30 min after mounting and a population field excitatory postsynaptic potential (fEPSP) of constant amplitude], we recorded control responses and applied tetanic stimuli consisting of two separate 1-sec stimulations, each at the test intensity at 100 Hz with the two stimulations separated by 5 sec.
Halogenated aromatic hydrocarbons suppress CA1 field excitatory postsynaptic potentials in rat hippocampal slices.
Hussain and colleagues monitored the amplitude of the field excitatory postsynaptic potential (fEPSP), which reflects the intensity of the response of hippocampal neurons to stimulation.
Methods: Field excitatory postsynaptic potentials (fEPSPs), spontaneous excitatory postsynaptic currents (sEPSCs) and miniature spontaneous excitatory postsynaptic currents (mEPSCs) were recorded, by using in vitro field potential electrophysiology and whole-cell patch clamp techniques in acute hippocampal slices from rats.
Therefore, in the present study we tested whether TDE can modulate dendritic field excitatory postsynaptic potentials (fEPSPs), which indicate the neuronal synaptic function, in Cornu Ammonis 1 (CA1) hippocampal slices of normal rats as found in current AChE-I drugs used for AD therapy.
This increase in L-type channels is correlated with increased failure of excitatory postsynaptic potentials as well as increased susceptibility to cell death.