excitatory amino acids

excitatory amino acids

[eksī′tətôr′ē]
one of a group of amino acids that affect the central nervous system by acting as neurotransmitters and in some cases as neurotoxins. Examples include glutamate and aspartate, which cause depolarization but may also trigger the death of neurons. Some excitatory amino acids are produced by plants and fungi and may be responsible for hypoxic or hypoglycemic brain damage.

excitatory amino acids

Aspartic acid and glutamic acid-amino acids that act on voltage-gated ion channels in the plasma membranes of cells of the nervous system to cause them to fire.
References in periodicals archive ?
Glutamate and the other excitatory amino acids have at least four different types of receptors.
Brain ischemia is profoundly debilitating, inducing the release of excitatory amino acids with subsequent receptor activation leading to calcium influx, metabolic and electrophysiological dysfunction and oxidative stress (including lipid peroxidation).
An analysis of excitatory amino acids, nitric oxide and prostaglandin EZ in the cerebrospinal fluid of pregnant women: the effect on labor pain.
NPS Allelix Corporation (Mississauga, Canada) has patented mediation of neurotransmission by excitatory amino acids (EAAs) such as glutamate via membrane-bound surface receptors.
The neuronal NMDA receptor can be stimulated by certain natural neurotransmitters called excitatory amino acids, such as glutamate, which are thought to contribute to normal processes such as learning and memory.
Cerebrospinal fluid (CSF) excitatory amino acids and cytokines were analyzed.
The brain uses excitatory amino acids as neurotransmitters.
Excitatory amino acids cause the death of neurons with toxicity, introduced via the aspartate receptor (aspartate is an excitatory amino acid).
Although the mechanisms behind both of these neuron-destroying events remain poorly understood, research suggests that much of the damage results from a series of biochemical reactions that start with the binding of so-called excitatory amino acids, such as glutamate, to nerve-cell docking sites called NMDA receptors.
Without these energy sources, the nerve cells in that area release toxic chemicals, including oxygen radicals and excitatory amino acids.

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