excision repair


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ex·ci·sion re·pair

the use of a complementary DNA strand as a template to replace a damaged segment of DNA.

excision repair

Correction of DNA damage by the removal of the damaged length of single strand by one of a number of enzymes capable of recognizing damaged nucleotides, and resynthesizing the correct nucleotide sequence complementary to the normal strand. The repair is catalyzed by DNA polymerase I and DNA ligase.

excision repair

the removal of damaged polynucleotide segments from DNA (e.g. THYMINE DIMERS produced by ultraviolet light) and replacement with a correct segment using DNA POLYMERASE and DNA LIGASE.
References in periodicals archive ?
Longevity has also failed to increase in most studies with mice with overexpression of base excision repair (BER) genes--a major pathway for repairing oxidative damage in DNA.
Nucleotide excision repair (NER) is a major DNA repair pathway that mammalian cells employ to maintain their genome intact and faithfully transmit it into their progeny.
Sancar was cited for his research that describes the mechanism of nucleotide excision repair, the mechanism that cells use to repair damage to DNA caused by ultraviolet radiation.
The cell also utilises nucleotide excision repair to correct defects caused by mutagenic substances, among other things, according to the statement.
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase.
Folate depletion impairs DNA excision repair in the colon of the rat.
Quantitative gene expression assays for excision repair (ERCC1), thymidylate synthase (TYMS), ribonucleotide reductase (RRM1) and other genes provide valuable information to help predict chemotherapy responses.
In this regard, the nucleotide excision repair (NER) [7] pathway is believed to be an essential mechanism for the repair of DNA-platinum adducts (5).
In the mid-1960s the prevalent model for excision repair in bacteria implicated some sort of enzymatic activity that specifically recognises the presence of damaged nucleotides in DNA and incises the damaged DNA strand close to the site of damage, thereby facilitating subsequent excision of a fragment of DNA containing the offending nucleotide.
These include the production of UV-absorbing pigments, like melanin, that act as physical barriers, and DNA repair systems, such as photoreactivation (photolyase enzyme) and excision repair (base and nucleotide excision repair).
The researchers demonstrated that B-cells are deficient in one of the main DNA repair pathways, known as Nucleotide Excision Repair.
For the first time in 1969, the crucial role played by DNA repair in preventing cancer was conclusively demonstrated by Cleaver (2), when he identified a defect in the pathway of excision repair among patients with Xeroderma Pigmentosum.