exacerbation

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exacerbation

 [eg-zas″er-ba´shun]
increase in severity of a disease or any of its symptoms.

ex·ac·er·ba·tion

(ek-zas'ĕr-bā'shŭn, ek-sas-),
Increased severity of a disease or any of its signs or symptoms.
[L. ex- acerbo, pp. -atus, to exasperate, increase, fr. acerbus, sour]

exacerbation

(ĭg-zăs′ər-bā′shən)
n.
An increase in the severity of a disease or in any of its signs or symptoms.

ex·ac′er·bate′ v.

exacerbation

[igzas′ərbā′shən]
Etymology: L, exacerbare, to provoke
an increase in the seriousness of a disease or disorder as marked by greater intensity in the signs or symptoms of the patient being treated.

ex·ac·er·ba·tion

(eg-zas'ĕr-bā'shŭn)
An increase in the severity of a disease or any of its signs or symptoms.
[L. ex- acerbo, pp. -atus, to exasperate, increase, fr. acerbus, sour]

exacerbation

An increase in severity or a causing of increased severity.

exacerbation

increased severity (of disease)

ex·ac·er·ba·tion

(eg-zas'ĕr-bā'shŭn)
Increased severity of a disease or any of its signs or symptoms.
[L. ex-acerbo, pp. -atus, to exasperate, increase, fr. acerbus, sour]

exacerbation

increase in severity of a disease or any of its clinical signs.
References in periodicals archive ?
Secondary endpoints for the study comparing Ultibro Breezhaler to SFC included superiority in terms of rate of all COPD exacerbations over the study duration and efficacy in terms of the following: time to first COPD exacerbation (mild/moderate/severe); rate and time to first moderate-to-severe COPD exacerbation; lung function (trough FEV1); health-related quality of life (as measured by the shortened version of the St George's Respiratory Questionnaire SGRQ-C ); rescue medication use and safety.
The likelihood of being exacerbation free at 1 year was 74% for a long-acting beta-agonist (LABA) plus ICS, vs.
The findings are important, as acute exacerbations of asthma during pregnancy may be the most significant risk factor for unfavorable pregnancy outcomes in women with asthma, the investigators said, noting that exacerbations occur in about 30% of pregnant women with asthma and are associated with complications such as preterm delivery, low birth weight, excessive antepartum hemorrhage, and cesarean delivery.
In another (the HI ACE study), 600 mg twice daily reduced COPD exacerbations and improved small airway function.
Results showed a significant reduction in severe exacerbations and subsequent hospitalization in the study population, making it the first COPD treatment to decrease the rate of hospitalization in patients already receiving multiple inhaled treatments.
There is sufficient evidence of an association between chronic ETS exposure and exacerbations of asthma in preschool-age children.
Of the 143 patients that completed the trial, the treatment group experienced significant reduction in the frequency of asthma exacerbation and frequency of catching a cold.
These exacerbations occur against a background of chronic persistent inflammation and structural changes that result in persistent symptoms and reduced lung function.
There was also no difference between the two groups in the amount of time until patients had their first exacerbation, or in measures of lung functioning, fatigue or the risk of death.
The secondary endpoint, the rate of pulmonary exacerbations (ie, the number of pulmonary exacerbations in 48 weeks) also showed a positive trend in favor of ataluren, with the rate in the ataluren group being 23% lower than the placebo group (p=.
Researchers then measured time to exacerbation of COPD.
Study subjects frequently had episodes of symptom worsening that resolved without ever turning into exacerbations.