etretinate


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etretinate

[etret′ināt]
a synthetic derivative of vitamin A used as an oral drug to treat psoriasis.
indications It is prescribed for severe recalcitrant psoriasis, including generalized pustular and erythrodermic psoriasis.
contraindications It is contraindicated for women who are of childbearing age unless a pregnancy test within 2 weeks of the start of therapy has negative results. Because of the risk of hyperostosis, the drug should not be given to children unless all alternative therapies have been exhausted. Intolerance to vitamin A derivative is another contraindication.
adverse effects Adverse effects may include benign intracranial hypertension, hepatitis, visual abnormalities including corneal damage, skeletal hyperostosis, peeling skin, alopecia, muscle cramps, and headache.

etretinate

Pharmacology A retinoic acid derivative that stimulates epithelial differentiation and inhibits the malignant transformation of skin and mucosa; it is a 2nd line agent for psoriasis in combination with PUVA, to ↓ dose of methoxsalen. See Psoriasis.

etretinate

(ĕ-trĕt′ĭn-āt)
A tretinoin drug formerly used to treat severe recalcitrant psoriasis.

CAUTION!

Etretinate must not be used by women who are pregnant or who intend to become pregnant. It should be prescribed only by physicians knowledgeable in the systemic use of retinoids.

etretinate

a synthetic retinoid, used orally in the treatment of skin diseases, particularly keratinization disorders. Like other synthetic retinoids, it is teratogenic and has a very long half-life.
References in periodicals archive ?
Hair repigmentation has previously been documented in association with a handful of other drugs used in cancer or rheumatology, including thalidomide, lenalidomide, erlotinib, adalimumab, and etretinate, but the mechanisms by which any of these agents affect hair or skin is poorly understood.
Etretinate 1 mg/kg/day is helpful in some cases, but the lesions recur.
A Japanese study combined the use of low-dose etretinate (0.
Several reports have described variable success in treating skin and vocal cord lesions with dermabrasion, carbon dioxide laser surgery, dimethyl sulfoxide, D-penicillamine, corticosteroids, acitretin, etretinate, carbon dioxide laser, Er:YAG laser, and surgical intervention (8, 9).
Sensory neuropathy associated long-terme etretinate (ET) therapy.
You cannot donate blood if you have ever taken etretinate (Tegison) or human pituitary-derived growth hormone.
There are reports that oral retinoids, such as etretinate, acitretin and isotretinoin, have been beneficial in treating keratoderma seen in PLS; although retinoids are not well tolerated in general.
Ishiura N, Komine M, Kadono T, Kikuchi K, Tamaki K: A case of milia en plaque successfully treated with oral etretinate.
Inefficacy of the synthetic aromatic retinoid etretinate and of its free acid on the in vitro differentiation of leukemic cells.
Numerous treatments, including prednisone, azathioprine, penicillamine, CsA, methotrexate, MMF, thalidomide, clofazimine, anti-CD20 monoclonal antibody, ECP, phototherapy with bath PUVA, UVA1 or UVB, etretinate or various combinations, have been tried with varying success in sclerodermatous GVHD (2), (3), (5), (15-22).
Impetigo herpetiformis in a primagravida: successful treatment with etretinate.