etretinate


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etretinate

[etret′ināt]
a synthetic derivative of vitamin A used as an oral drug to treat psoriasis.
indications It is prescribed for severe recalcitrant psoriasis, including generalized pustular and erythrodermic psoriasis.
contraindications It is contraindicated for women who are of childbearing age unless a pregnancy test within 2 weeks of the start of therapy has negative results. Because of the risk of hyperostosis, the drug should not be given to children unless all alternative therapies have been exhausted. Intolerance to vitamin A derivative is another contraindication.
adverse effects Adverse effects may include benign intracranial hypertension, hepatitis, visual abnormalities including corneal damage, skeletal hyperostosis, peeling skin, alopecia, muscle cramps, and headache.

etretinate

Pharmacology A retinoic acid derivative that stimulates epithelial differentiation and inhibits the malignant transformation of skin and mucosa; it is a 2nd line agent for psoriasis in combination with PUVA, to ↓ dose of methoxsalen. See Psoriasis.

etretinate

(ĕ-trĕt′ĭn-āt)
A tretinoin drug formerly used to treat severe recalcitrant psoriasis.

CAUTION!

Etretinate must not be used by women who are pregnant or who intend to become pregnant. It should be prescribed only by physicians knowledgeable in the systemic use of retinoids.

etretinate

a synthetic retinoid, used orally in the treatment of skin diseases, particularly keratinization disorders. Like other synthetic retinoids, it is teratogenic and has a very long half-life.
References in periodicals archive ?
Sensory neuropathy associated long-terme etretinate (ET) therapy.
Ishiura N, Komine M, Kadono T, Kikuchi K, Tamaki K: A case of milia en plaque successfully treated with oral etretinate.
Inefficacy of the synthetic aromatic retinoid etretinate and of its free acid on the in vitro differentiation of leukemic cells.
Numerous treatments, including prednisone, azathioprine, penicillamine, CsA, methotrexate, MMF, thalidomide, clofazimine, anti-CD20 monoclonal antibody, ECP, phototherapy with bath PUVA, UVA1 or UVB, etretinate or various combinations, have been tried with varying success in sclerodermatous GVHD (2), (3), (5), (15-22).
Synthetic retinoids, etretinate (Tigason[R]) and acitretin (Neotigason[R]) were developed to overcome this side-effect.
22] In another prospective, randomized, double-blind study, Studer and colleagues evaluated the effect of etretinate in 90 patients having undergone transurethral bladder tumour resection for stage Ta and T1 cancers.
This is a rare feature of isotretinoin treatment (Figure 7) and is more often observed with acitretin or etretinate.
Various therapeutic modalities such as systemic antihistamines, topical or intralesional corticosteroids, etretinate, narrow-band ultraviolet B phototherapy, and dermabrasion/epidermal scraping have been useful (3, 9, 13-16).
Evidence for a probable causal relationship between tretinoin, acitretin, and etretinate and intracranial hypertension.
The risk with this combination is that, in the presence of alcohol, acitretin is converted to etretinate, which has a much longer period of teratogenicity.
Some patients require treatment with high doses of vitamin A or synthetic retinoids such as etretinate.
Rather, the study began as an evaluation of two drugs, Accutane and Etretinate, for their ability to decrease the production of cat allergen.