etoposide


Also found in: Dictionary, Acronyms, Wikipedia.
Related to etoposide: cisplatin, Ifosfamide

etoposide

 [e-to-po´sīd]
a semisynthetic derivative of podophyllotoxin used as the base or the phosphate salt as an antineoplastic agent in treatment of carcinoma of the testes, lung, or bladder, lymphoma, acute myelocytic leukemia, Ewing's sarcoma, and Kaposi's sarcoma; administered orally or intravenously.

etoposide

/eto·po·side/ (e″to-po´sīd) a semisynthetic derivative of podophyllotoxin used as the base or the phosphate salt as an antineoplastic, particularly for treating testicular tumors and small cell lung carcinoma.

etoposide

(ē′tə-pō′sīd′)
n.
A semisynthetic derivative of podophyllotoxin that is a mitotic inhibitor used in the treatment of refractory testicular tumors and small cell lung cancer.

etoposide

an antineoplastic or chemotherapeutic agent and mitotic inhibitor.
indications It is prescribed in the treatment of several forms of cancer, including lymphomas, cancer of the testicles and prostate, and small-cell lung cancer, to prevent tumor cells from dividing and spreading.
contraindications It should not be used if there is an allergy to etoposide or podophyllum. There is a potential adverse effect to the fetus if used by a pregnant patient, and the drug should not be used if breastfeeding.
adverse effects The side effects most often reported include chills, rapid heartbeat, painful or difficult breathing, decreased blood pressure, hair loss, rash, itching, skin discoloration, and digestive disorders.

etoposide

Oncology A chemotherapeutic active against monocytic leukemia, CNS lymphoma, refractory small cell carcinoma, testicular CA, and KS, which may be co-administered with cyclophosphamide and doxorubicin Adverse effects BM toxicity, hair loss, nausea, incoordination, stomatitis, dyspnea, anorexia. See AIDS, ALL.

etoposide

An anticancer drug derived from a plant poison epipodophyllotoxin. It is used chiefly in the maintenance treatment of acute leukaemia after remission has been achieved and the bone marrow has recovered. It has been given by mouth to treat lung cancer. The drug is on the WHO official list. A brand name is Vepeside.

etoposide

a derivative of podophyllotoxin with antineoplastic activity; used in the treatment of leukemias.
References in periodicals archive ?
Chest computed tomography on day 2 of bleomycin, etoposide, and cisplatin (BEP), immediately after onset of choriocarcinoma syndrome.
Results of a phase II study with doxorubicin, etoposide, and cisplatin in patients with fully characterized small-cell carcinoma of the prostate.
A randomized trial of etoposide + cisplatin versus vinblastine + bleomycin + cisplatin + cyclophosphamide + dactinomycin in patients with good-prognosis germ cell tumours.
In in vitro experiments, STA-9090 reduced the expression of WT1 in a dose-dependent manner and induced apoptosis in myeloid leukemia cells, and the combination of STA-9090 and etoposide displayed enhanced cytotoxicity relative to either agent alone.
MPI-176716 was tested in parallel with cisplatin and etoposide, two common anti-neoplastic compounds used to treat certain ovarian cancer, bladder cancer, lung cancer, testicular cancer and non-hodgkins lymphoma cases.
Abstract #5372 - Synergy of Histone Deacetylase Inhibitors, Belinostat and Depsipeptide, With DNA Damaging Agents, Etoposide and Cisplatin, In Small Cell Lung Cancer Cell Lines
Escalating doses of Genasense plus carboplatin and etoposide, two commonly used chemotherapy agents, were administered to evaluate safety and potential efficacy.
In this multi-center, randomized, controlled study, the clinical effect of a combination of carboplatin, etoposide and obatoclax (the "CEO" regimen) is being compared to a standard chemotherapeutic regimen of carboplatin and etoposide alone (the control arm).
Contract notice: Completion of a non-exclusive discount agreement pursuant to A* 130 abs 8 sgb v for drug etoposide -.
All patients received cisplatin, 50 mg/m2, administered intravenously on days 1 and 8, and etoposide, 50 mg/m2, administered intravenously each day for five days.
Based on the synergies observed between obatoclax and carboplatin and etoposide in preclinical studies, and by the safety profile and high response rates witnessed in the vast majority of SCLC patients in our earlier Phase 1b trial, we are hopeful about the potential of obatoclax to become an important therapeutic for these cancer patients," commented Jean Viallet, M.
Request for proposal: Delivery of the drug etoposide