etoposide


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Related to etoposide: cisplatin, Ifosfamide

etoposide

 [e-to-po´sīd]
a semisynthetic derivative of podophyllotoxin used as the base or the phosphate salt as an antineoplastic agent in treatment of carcinoma of the testes, lung, or bladder, lymphoma, acute myelocytic leukemia, Ewing's sarcoma, and Kaposi's sarcoma; administered orally or intravenously.

etoposide

/eto·po·side/ (e″to-po´sīd) a semisynthetic derivative of podophyllotoxin used as the base or the phosphate salt as an antineoplastic, particularly for treating testicular tumors and small cell lung carcinoma.

etoposide

(ē′tə-pō′sīd′)
n.
A semisynthetic derivative of podophyllotoxin that is a mitotic inhibitor used in the treatment of refractory testicular tumors and small cell lung cancer.

etoposide

an antineoplastic or chemotherapeutic agent and mitotic inhibitor.
indications It is prescribed in the treatment of several forms of cancer, including lymphomas, cancer of the testicles and prostate, and small-cell lung cancer, to prevent tumor cells from dividing and spreading.
contraindications It should not be used if there is an allergy to etoposide or podophyllum. There is a potential adverse effect to the fetus if used by a pregnant patient, and the drug should not be used if breastfeeding.
adverse effects The side effects most often reported include chills, rapid heartbeat, painful or difficult breathing, decreased blood pressure, hair loss, rash, itching, skin discoloration, and digestive disorders.

etoposide

Oncology A chemotherapeutic active against monocytic leukemia, CNS lymphoma, refractory small cell carcinoma, testicular CA, and KS, which may be co-administered with cyclophosphamide and doxorubicin Adverse effects BM toxicity, hair loss, nausea, incoordination, stomatitis, dyspnea, anorexia. See AIDS, ALL.

etoposide

An anticancer drug derived from a plant poison epipodophyllotoxin. It is used chiefly in the maintenance treatment of acute leukaemia after remission has been achieved and the bone marrow has recovered. It has been given by mouth to treat lung cancer. The drug is on the WHO official list. A brand name is Vepeside.

etoposide

a derivative of podophyllotoxin with antineoplastic activity; used in the treatment of leukemias.
References in periodicals archive ?
Responses to high-dose TI-CE chemotherapy regimen in patients with relapsed germ cell tumours (n=79 patients) Response n % Combined % CR (chemotherapy 13 17% alone) 45% CR 70% CR (chemotherapy + 22 28% Favourable surgery) response Partial response 20 25% with negative markers CR: complete response; TI-CE: paclitaxel [T] plus ifosfamide [I] followed by high-dose carboplatin [C] plus etoposide [E].
A) (Top row) Electron micrographs of wild-type MEFs and Atg5-deficient MEFs treated with etoposide (10 [micro]M) for 18 h.
Entecavir and etoposide were eluted through column C18 ODS Hypersil column of 150 mm x 4.
Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide.
Treatment ofpoorly differenciated neuroendocrine tumors with etoposide and cisplatin.
5), (9) Various regimens adding cisplatin as the main agent have been used, including etoposide, cyclophosphamide, doxorubicin and vincristine; carboplatin and etoposide; carboplatin and taxanes; and cisplatin, ifosfamide, and etoposide.
to oral Etoposide in patients free from disease after their second metastatic relapse.
The researchers compared various chemotherapy regimens and IFRT doses and found that outcomes were similar when 30 Gy of IFRT was combined with either four cycles of ABVD (doxorubicine, bleomycin, vinblastine, and dacarbazine) or four cycles of BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone).
Other tests showed juices can affect the absorption of anti-cancer drugs such as etoposide (Etopophos, Vepesid), beta blockers such as tenormin (Atenolol) and talinolol (Cordanum), and antibiotics such as ciprofloxacin (Cipro), levofloxacin (Levaquin) and itraconazole (Sporanox).
Name of trial A Phase Ib/II Study of CYT997 in Combination with Carboplatin and Etoposide in Relapsed Glioblastoma Multiforme (CCL08001).
To date, grapefruit, orange and apple juices have been shown to lower the absorption of etoposide (an anti-cancer agent), several beta-blockers (used to treat high blood pressure and prevent heart attacks), cyclosporine (which prevents rejection of transplanted organs) and certain antibiotics.
Drugs whose effectiveness was lowered included anti-cancer agent etoposide, beta blockers and cyclosporine, which prevents rejection of transplanted organs.