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etidronate disodium |
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etidronate disodium [etid′rənāt] a regulator of calcium metabolism. Also called sodium etidronate. indications It is prescribed in the treatment of Paget's disease and heterotopic ossification caused by injury to the spinal cord and after total hip replacement. contraindication There are no known contraindications. adverse effects Among the more serious adverse effects are bone pain both at pagetic sites and at previously asymptomatic sites, GI disturbances, and elevated serum phosphate concentrations. etidronate disodium (ē´t n brand name: Didronel IV; drug class: antihypercalcemic; action: decreases bone resorption and new bone development (accretion); uses: Paget's disease, heterotopic ossification, hypercalemia of malignancy. etidronate disodium Didronel Pharmacologic class: Bisphosphonate Therapeutic class: Bone resorption inhibitor, hypocalcemic agent Pregnancy risk category B (oral use), C (I.V. use) ActionBlocks calcium absorption, slowing bone metabolism and reducing bone resorption and formation AvailabilityInjection: 300 mg/ampule in 6-ml ampules Tablets: 200 mg, 400 mg ⊘Indications and dosages ➣ Paget's disease Adults: 5 to 10 mg/kg P.O. daily as a single dose for up to 6 months, or 11 to 20 mg/kg P.O. daily for up to 3 months ➣ Heterotopic ossification after hip replacement Adults: 20 mg/kg P.O. daily for 1 month before and 3 months after surgery ➣ Heterotopic ossification in spinal cord injury Adults: Initially, 20 mg/kg P.O. daily for 2 weeks, decreased to 10 mg/kg P.O. daily for 10 weeks ➣ Hypercalcemia related to cancer Adults: 7.5 mg/kg/day I.V. infused over at least 2 hours for 3 consecutive days; may continue infusion for up to 7 days if necessary. P.O. dosing may begin after last infusion. Contraindications• Hypersensitivity to drug or its components PrecautionsUse cautiously in: Administration• For I.V. use, dilute with 250 ml of normal saline solution. Infuse slowly over at least 2 hours.
Adverse reactionsAll reactions occur only with I.V. use unless otherwise noted. CNS: seizures GI: nausea, constipation, stomatitis Hematologic: anemia Metabolic: hypomagnesemia, hypophosphatemia, fluid overload Musculoskeletal: bone pain and tenderness, fractures (all with oral use) Respiratory: dyspnea Skin: rash (with oral use) Other: taste loss, metallic taste, fever InteractionsDrug-drug. Antacids; buffers containing aluminum, calcium, iron, or magnesium; mineral supplements: decreased etidronate absorption Calcitonin: additive hypocalcemic effect Warfarin: increased prothrombin time Drug-diagnostic tests. Blood urea nitrogen (BUN), creatinine: increased levels Calcium, magnesium: decreased levels Liver function tests: elevated values Drug-food. Foods high in aluminum, calcium, iron, or magnesium: decreased etidronate absorption Patient monitoring• Monitor fluid intake and output. Patient teaching• Instruct patient not to take drug with food because of decreased drug absorption. etidronate disodium Didronel® Metabolism An organic biphosphonate used to manage osteoporosis, Paget's disease of bone–osteitis deformans, heterotopic ossification, hypercalcemia of CA. See Coherence therapy, Osteoporosis. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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In their three-year study, the scientists found that low doses of etidronate disodium -- a drug known to inhibit osteoclast activity in patients with Paget's disease, another bone disorder -- showed similar effectiveness in osteoporotic women without suppressing bone mineralization as higher doses had done in previous studies. comparative study with etidronate disodium 400 mg/day. comparative study with etidronate disodium 400 mg/day. |
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