ethylenediaminetetraacetic acid


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ethylenediaminetetraacetic acid

 (EDTA) [eth″ĭ-lēn-di″ah-mēn-tet″rah-ah-se´tik]
a chelating agent that binds calcium and other metals; used as an anticoagulant for preserving blood specimens. Also used medicinally; see edetate. Called also edetic acid.

eth·yl·ene·di·a·mine·tet·ra·a·ce·tic ac·id (EDTA),

(eth'il-ēn-dī'ă-mēn-tet'ă-sē'tik as'id),
A chelating agent used to remove multivalent cations from solution as chelates, and used in biochemical research to remove Mg2+, Fe2+, among other elements, from reactions affected by such ions. As the sodium salt, used as a water softener, to stabilize drugs rapidly decomposed in the presence of traces of metal ions, and as an anticoagulant; as the sodium calcium salt, used to remove radium, lead, strontium, plutonium, and cadmium from hard tissue, forming stable un-ionized soluble compounds that are excreted by the kidneys. Compare: EGTA.
Synonym(s): edathamil, edetic acid

ethylenediaminetetraacetic acid

/eth·y·lene·di·a·mine·tet·ra·a·ce·tic ac·id/ (EDTA) (-di″ah-mēn-tet″rah-ah-se´tik) a chelating agent that binds calcium and other metals, used as an anticoagulant for preserving blood specimens; also used to treat lead poisoning and hypercalcemia (see edetate ).

EDTA

Alternative medicine
See Chelation therapy.
 
Chemistry
A chelating agent that binds divalent (e.g., arsenic, calcium, lead and magnesium) and trivalent cations.
 
Lab medicine
EDTA is added to blood collection tubes to transport specimens for analysis in chemistry (e.g., CEA, lead, renin) and haematology (it is the preferred anticoagulant for blood cell counts, coagulation studies, haemoglobin electrophoresis and erythrocyte sedimentation rate); in the blood bank, EDTA prevents haemolysis by inhibiting complement binding.
 
Toxicology
EDTA is used to manage lead and other heavy metal intoxication.

eth·yl·ene·di·a·mine·tet·ra·a·ce·tic ac·id

(EDTA) (eth'i-lēn-dī'ă-mēn-tet'ră-ă-sē'tik as'id)
A chelating agent and anticoagulant; added to blood specimens for hematologic and other tests.
References in periodicals archive ?
Reported etiologies include hemolysis of the sample, delayed separation of serum from red cells, exercise of the patient's arm with the occlusive cuff in place, inappropriate venipuncture site (ie, above the potassium-infusion site), and inappropriate collection containers (eg, ethylenediaminetetraacetic acid [EDTA] or potassium oxalate Vacutainers).
When performing a provocative urine challenge test, one of three chelating agents is used: calcium ethylenediaminetetraacetic acid (CaEDTA), dimercaptosuccinic acid (DMSA), or 2,3-dimercapto-1-propane sulfonic acid (DMPS).
The researchers also determined the impact of mixed tocopherol and ethylenediaminetetraacetic acid (EDTA) on the oxidative stability of liquid and freeze-dried emulsions.
Preparation of LDL: Ethylenediaminetetraacetic acid (EDTA)-containing plasma samples (1 mg/ml) were prepared from blood of 10 healthy donors ([male] = 5, [female] = 5, 23-40 years old), pooled and supplemented with sucrose (0.
0), 1% nonionic detergent IGEPAL CA-630 (Sigma Chemical Company), 20 mM ethylenediaminetetraacetic acid, 150 mmol/L sodium chloride, 1 mmol/L magnesium chloride, 10 mM tetrasodium pyrophosphate, 100 mM sodium fluoride, 2 mM sodium orthovanadate, 10 [micro]g/mL leupeptin, 10 [micro]g/mL aprotinin, and 1 mM phenylmethylsulfonyl fluoride.
6 Mean platelet volume and platelet count were assayed on ethylenediaminetetraacetic acid anticoagulated specimens using an ADVIA 120 analyzer (Bayer Diagnostics, Newbury, United Kingdom).
omega][epsilon]]-Nitro-L-arginine methyl ester (L-NAME) hydrochloride; ethyleneglycol bis ([beta]-aminoethylether)-N,N,N'N'-tetraacetic acid (EGTA) (all from Sigma); ethylenediaminetetraacetic acid dihydrate dissodium salt (EDTA) (Merck).

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