ethylenediaminetetraacetic acid


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ethylenediaminetetraacetic acid

 (EDTA) [eth″ĭ-lēn-di″ah-mēn-tet″rah-ah-se´tik]
a chelating agent that binds calcium and other metals; used as an anticoagulant for preserving blood specimens. Also used medicinally; see edetate. Called also edetic acid.

eth·yl·ene·di·a·mine·tet·ra·a·ce·tic ac·id (EDTA),

(eth'il-ēn-dī'ă-mēn-tet'ă-sē'tik as'id),
A chelating agent used to remove multivalent cations from solution as chelates, and used in biochemical research to remove Mg2+, Fe2+, among other elements, from reactions affected by such ions. As the sodium salt, used as a water softener, to stabilize drugs rapidly decomposed in the presence of traces of metal ions, and as an anticoagulant; as the sodium calcium salt, used to remove radium, lead, strontium, plutonium, and cadmium from hard tissue, forming stable un-ionized soluble compounds that are excreted by the kidneys. Compare: EGTA.
Synonym(s): edathamil, edetic acid

ethylenediaminetetraacetic acid

/eth·y·lene·di·a·mine·tet·ra·a·ce·tic ac·id/ (EDTA) (-di″ah-mēn-tet″rah-ah-se´tik) a chelating agent that binds calcium and other metals, used as an anticoagulant for preserving blood specimens; also used to treat lead poisoning and hypercalcemia (see edetate ).

EDTA

Alternative medicine
See Chelation therapy.
 
Chemistry
A chelating agent that binds divalent (e.g., arsenic, calcium, lead and magnesium) and trivalent cations.
 
Lab medicine
EDTA is added to blood collection tubes to transport specimens for analysis in chemistry (e.g., CEA, lead, renin) and haematology (it is the preferred anticoagulant for blood cell counts, coagulation studies, haemoglobin electrophoresis and erythrocyte sedimentation rate); in the blood bank, EDTA prevents haemolysis by inhibiting complement binding.
 
Toxicology
EDTA is used to manage lead and other heavy metal intoxication.

eth·yl·ene·di·a·mine·tet·ra·a·ce·tic ac·id

(EDTA) (eth'i-lēn-dī'ă-mēn-tet'ră-ă-sē'tik as'id)
A chelating agent and anticoagulant; added to blood specimens for hematologic and other tests.
References in periodicals archive ?
Effects of different exposure times and concentrations of sodium hypochlorite/ ethylenediaminetetraacetic acid on the structural integrity of mineralized dentin.
In general, the treatments combining sodium benzoate and lactic acid or sodium benzoate, lactic acid and disodium ethylenediaminetetraacetic acid were more effective against E.
Precapillary complexation of cations has been studied by using complexing agents such as ethylenediaminetetraacetic acid (EDTA) [31] and pyridine-2,6-dicarboxylic acid (PDC) [32].
Role of iron and ethylenediaminetetraacetic acid in the bactericidal activity of a superoxide anion-generating system.
1 [micro]M ethylenediaminetetraacetic acid (EDTA; ethylenediamine-N,N,N',N'-tetraacetic acid), and 50 mM phosphate buffer (pH 7.
Although proponents of chelation therapy hypothesize that chelation with ethylenediaminetetraacetic acid might improve ischemia by liberating the calcium in atheromatous plaques, the results of this study show that chelation "remains unproved in the treatment of ischemic heart disease," the investigators said (JAMA 287[4]:481-86, 2001).
Some formulas have a base of ethylenediaminetetraacetic acid (EDTA), a molecule resembling an amino acid.
This study was conducted at the Jackson State University greenhouse to evaluate whether the addition of a synthetic chelate, ethylenediaminetetraacetic acid (EDTA), can further enhance the effectiveness of coffeeweed (Sesbania exaltata Raf.
1999) was pulled through each well by gentle vacuum, followed by 200 [micro]L of RPA product (hybridized, RNase-treated probe and target RNA) in ice-cold 10 mM NaOH / 1 mM ethylenediaminetetraacetic acid (EDTA).
The investigators found that monolaurin, when combined with ethylenediaminetetraacetic acid (EDTA), was effective against Escherichia coli and Bacillus subtilis, but not against Staphylococcus aureus.
NaFeEDTA or sodium iron (Fe3+) ethylenediaminetetraacetic acid is a water soluble iron compound used to fortify especially grain-based products.

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