ethylenediamine(redirected from ethylenediamine tetra-acetic acid)
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aminophylline (theophylline, ethylenediamine)
Amnivent (UK), Phyllocontin (UK)
Pharmacologic class: Xanthine
Therapeutic class: Bronchodilator
Pregnancy risk category C
Unclear. Thought to directly relax smooth muscle of bronchial airways and increase pulmonary blood flow by inhibiting phosphodiesterase.
Injection: 250 mg/10 ml
Oral liquid: 105 mg/5 ml
Tablets: 100 mg, 200 mg
⊘Indications and dosages
➣ Symptomatic relief of bronchospasm in patients with acute symptoms who require rapid theophyllinization
Adults (nonsmokers): 0.7 mg/kg/hour I.V. for first 12 hours. Maintenance dosage is 0.5 mg/kg/hour I.V.
Children ages 9 to 16: 1 mg/kg/hour I.V. for first 12 hours. Maintenance dosage is 0.8 mg/kg/hour I.V.
Children ages 6 months to 9 years: 1.2 mg/kg/hour I.V. for first 12 hours. Maintenance dosage is 1 mg/kg/hour I.V.
➣ Chronic bronchial asthma
Adults and children: Dosage is highly individualized. Common initial dosage is 16 mg/kg/24 hours I.V. or 400 mg/24 hours I.V. in divided doses at 6- or 8hour intervals. If needed, dosage may be increased 25% at 3-day intervals.
• Heart failure
• Hepatic disease
• Elderly patients
• Dyspnea in patients with chronic obstructive pulmonary disease (COPD)
• Hypersensitivity to xanthine compounds or ethylenediamine
• Seizure disorders
Use cautiously in:
• COPD, diabetes mellitus, glaucoma, renal or hepatic disease, heart failure or other cardiac or circulatory impairment, hypertension, hyperthyroidism, peptic ulcer, severe hypoxemia
• active peptic ulcer disease
• elderly patients
• neonates, infants, and young children.
• For I.V. use, dilute according to label directions and infuse at a rate no faster than 25 mg/minute.
• Don't give in I.V. solutions containing invert sugar, fructose, or fat emulsions.
• Give oral form at meals with 8 oz of water.
CNS: irritability, dizziness, nervousness, restlessness, headache, insomnia, stammering speech, abnormal behavior, mutism, unresponsiveness alternating with hyperactivity, seizures
CV: palpitations, sinus tachycardia, extrasystoles, marked hypotension, arrhythmias, circulatory failure
GI: nausea, vomiting, diarrhea, epigastric pain, hematemesis, gastroesophageal reflux, anorexia
GU: urine retention (in men with enlarged prostate), diuresis, increased excretion of renal tubular cells and red blood cells, proteinuria
Musculoskeletal: muscle twitching
Respiratory: tachypnea, respiratory arrest
Other: fever, hypersensitivity reactions (including exfoliative dermatitis and urticaria)
Drug-drug.Adenosine: decreased antiarrhythmic effect of adenosine
Barbiturates, nicotine, phenytoin, rifampin: decreased aminophylline blood level
Beta-adrenergic blockers: antagonism of aminophylline effects
Calcium channel blockers, cimetidine, ciprofloxacin, disulfiram, erythromycin, hormonal contraceptives, influenza vaccine, interferon, methotrexate: elevated aminophylline blood level
Carbamazepine, isoniazid, loop diuretics (such as furosemide): increased or decreased aminophylline blood level
Ephedrine, other sympathomimetics: toxicity, arrhythmias
Lithium: increased lithium excretion
Drug-diagnostic tests.Aspartate aminotransferase, glucose: increased levels
Drug-herbs.Cayenne: increased risk of aminophylline toxicity
Drug-behaviors.Smoking: increased aminophylline elimination
☞ Monitor aminophylline blood level. Adjust dosage if patient has signs or symptoms of toxicity (tachycardia, headache, anorexia, nausea, vomiting, diarrhea, restlessness, and irritability).
• Assess for arrhythmias, especially after giving loading dose.
• Check vital signs and fluid intake and output.
• Monitor patient's response to drug, and assess pulmonary function test results.
• Advise patient to take oral doses at meals with 8 oz of water.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Tell patient to minimize GI upset by eating small, frequent servings of food and drinking plenty of fluids.
• Advise patient to establish effective bedtime routine to minimize insomnia.
• Caution patient not to change aminophylline brands.
• If patient smokes, tell him to notify prescriber if he stops smoking; dosage may need to be adjusted.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.