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ethionamide

   Also found in: Wikipedia 0.01 sec.
ethionamide /ethi·on·am·ide/ (ĕ-thi″on-am´īd) an antibacterial, effective against Mycobacterium tuberculosis; used in the treatment of pulmonary tuberculosis.
ethionamide
[eth′ē·ənam′īd]
a tuberculostatic antibacterial.
indication It is prescribed for the treatment of tuberculosis in conjunction with other drugs when frontline therapy has failed.
contraindications Existing liver damage or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse effects are skin rash, jaundice, mental depression, and GI side effects.

ethionamide [ĕ-thi″on-am´īd]
an antibacterial effective against Mycobacterium tuberculosis; used in the treatment of pulmonary tuberculosis, administered orally.

ethionamide
(eth´ēon´mīd´),
n brand name: Trecator-SC;
drug class: antitubercular;
action: bacteriostatic against Mycobacterium tuberculosis; may inhibit protein synthesis;
uses: pulmonary, extrapulmonary tuberculosis when other antitubercular drugs have failed.


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The organism was resistant to clarithromycin and ethionamide, but sensitive to amikacin, ethambutol, and rifampicin.
tuberculosis isolates resistant to streptomycin, 119 (65%) to ethambutol, 103 (56%) to rifabutin, 79 (43%) to pyrazinamide, 23 (13%) to amikacin, 20 (11%) to a fluoroquinolone, 19 (10%) to capreomycin, 36 (19%) to ethionamide, 15 (8%) to para-aminosalicylic acid, 9 (5%) to cycloserine, 3 (2%) to kanamycin, and 1 (<1%) to linezolid.
A daily regimen of 12,000 mg para-aminosalicylic acid, 800 mg ofloxacin, 750 mg cycloserine, 750 mg ethionamide, 150 mg thiacetazone, and 1,000 mg amikacin was administered for 2 years, with the diagnosis of multidrug-resistant tuberculosis.
 
 
 
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