ethionamide


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Related to ethionamide: isoniazid, Pyrazinamide, cycloserine, ethambutol

ethionamide

 [ĕ-thi″on-am´īd]
an antibacterial effective against Mycobacterium tuberculosis; used in the treatment of pulmonary tuberculosis, administered orally.

ethionamide

/ethi·on·am·ide/ (ĕ-thi″on-am´īd) an antibacterial, effective against Mycobacterium tuberculosis; used in the treatment of pulmonary tuberculosis.

ethionamide

[eth′ē·ənam′īd]
a tuberculostatic antibacterial.
indication It is prescribed for the treatment of tuberculosis in conjunction with other drugs when frontline therapy has failed.
contraindications Existing liver damage or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse effects are skin rash, jaundice, mental depression, and GI side effects.

ethionamide

A drug used in the treatment of LEPROSY or in cases of TUBERCULOSIS resistant to other drugs. The drug is on the WHO official list.

ethionamide

(eth´ēon´əmīd´),
n brand name: Trecator-SC;
drug class: antitubercular;
action: bacteriostatic against Mycobacterium tuberculosis; may inhibit protein synthesis;
uses: pulmonary, extrapulmonary tuberculosis when other antitubercular drugs have failed.
References in periodicals archive ?
Treatment regimen: The standardized regimen consisted of an intensive phase (IP) of 6-9 months with 6 drugs, namely kanamycin (Km), ofloxacin (Ofx), ethionamide (Eto), pyrazinamide (Z), ethambutol (E), and cycloserine (Cs) given daily.
Almost all acquired resistance was to ofloxacin, capreomycin, or kanamycin; 2 patients each had isolates with acquired resistance to ethionamide and p-aminosalicylic acid.
Add [greater than or equal Ethionamide to] 2 drugs until at least Terizidone */cycloserine four likely effective drugs in Para-aminosalicylic acid regimen (DST is not reliable for these) 5.
He was referred to the provincial drug-resistant TB unit (approximately 250 km from home) and was commenced on a standardised regimen of kanamycin, moxifloxacin, ethionamide, terizidone, pyrazinamide and isoniazid.
2, rifampicin--40, pyrazinamide--100, ethambutol--2, streptomycin--4, kanamycin--64, ciprofloxacin--8, ofloxacin--8, ethionamide --320, cycloserine--160, para-aminosalicylic acid--4, thiacetazone--4, and clarithromycin--128.
35,36) Cycloserine, ethionamide, and isoniazid (INH) have all been evaluated for MAC therapies, but resistance is common.
Susceptibility testing for the baseline and the last follow-up (final) isolates from each patient were determined for isoniazid, rifampin, ethambutol, streptomycin, kanamycin, amikacin, capreomycin, ofloxacin, ethionamide, and paraaminosalicylic acid.
Alternatives such as streptomycin and ethionamide are of limited use in TBM owing to poor CNS penetration, dose-limiting toxicity and intolerable gastrointestinal side-effects in adults.
Shared side-effects of TB treatment and ART Side-effects ART TB treatment Nausea AZT, ddI, PIs Pyrazinamide, ethionamide Hepatitis NVP, EFV, PIs Rifampicin, isoniazid, (NRTIs can cause pyrazinamide and many second- steatohepatitis) line drugs including quinolones Peripheral D4T, ddI Isoniazid, ethionamide, neuropathy terizidone/cycloserine Renal TDF Aminoglycosides impairment Rash NVP, EFV, RAL Rifampicin, isoniazid, pyrazinamide, ethambutol, streptomycin and many second-line drugs including quinolones Neuropsychiatric EFV Terizidone/cycloserine, quinolones, isoniazid AZT = zidovudine; ddI = didanosine; PIs = protease inhibitors; NVP = nevirapine; EFV = efavirenz; NRTIs = nucleoside reverse transcriptase inhibitors; D4T = stavudine; TDF = tenofovir.
rifampicin 20 mg/ kg/day, isoniazid 20 mg/kg/day, ethionamide 20 mg/kg/day and pyrazinamide 40 mg/kg/day.
Drugs tested include capreomycin, kanamycin, ethionamide, cycloserine, para-amino salicylic acid, amikacin, ciprofloxacin, and ofloxacin.
Dalene von Delft was referred to him with resistance to isoniazide, rifampicin, ethambutol and ethionamide.