estrone


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Related to estrone: estriol

estrone

 [es´trōn]
an estrogen isolated from pregnancy urine, the human placenta, and palm kernel oil, and also prepared synthetically; used in estrogen replacement therapy for hypogonadism, ovariectomy, primary ovarian failure, atrophic vaginitis, vasomotor menopausal symptoms such as hot flashes, and vulvar atrophy, and in the treatment of dysfunctional uterine bleeding and advanced prostate cancer. Administered intramuscularly or intravaginally. See also conjugated estrogens and esterified estrogens.

es·trone (E1),

(es'trōn),
A metabolite of 17β-estradiol, commonly found in urine, ovaries, and placenta; has considerably less biologic activity than the parent hormone.

estrone

/es·trone/ (es´trōn) an estrogen isolated from pregnancy urine, human placenta, palm kernel oil, and other sources, also prepared synthetically; for properties and uses, see estrogen.

estrone

(ĕs′trōn′)
n.
An estrogenic hormone, C18H22O2, that is secreted by the ovaries and by fatty tissue. It is the main form of estrogen in postmenopausal women.

estrone

[es′trōn]
a relatively potent endogenous estrogen. Also spelled oestrone.

estrone

E1 An estrogen with very low biologic activity that is the major source of estrogen in children and postmenopausal ♀ ↑ in pregnancy, postmenopausal, ↑ age, obesity, luteal phase of menstrual cycle ↓ in hypogonadism. See Androstendione.

es·trone

(es'trōn)
A metabolite of 17β-estradiol, commonly found in urine, ovaries, and placenta, with considerably less biologic activity than the parent hormone.
Synonym(s): oestrone.

estrone

an oxidation product of estradiol, and androstenedione in the animal body; less active than estradiol and produced in greater quantities in the pregnant female.

estrone sulfate test
1. a pregnancy diagnosis carried out on cow's milk; has very high accuracy but impractical because of lateness of applicability, e.g. maximum at day 105 of pregnancy.
2. a test using serum which detects the presence of a retained testicle in horses with no testicles in the scrotum but which are demonstrating sexual behavior.
References in periodicals archive ?
Later calli were transferred to MS medium containing 17[beta]-estradiol, estrone, progesterone and androsterone with four different doses (0, 10-4 m mol L-1 and 10-8 m mol L-1 and 10-12 m mol L-1) for 50 days and subcultured in 30 days.
Taken together, the steroidogenic profile of our co-culture model--given the lack of quantifiable testosterone production but great production of DHEA and, to a lesser extent, androstenedione--indicates that estradiol is produced mainly via the aromatization of androstenedione to estrone and its subsequent rapid conversion to estradiol by 17[beta]-hydroxysteroid dehydrogenase type 1 (HSD17B1).
Once synthesised, E1 can be converted to estrone sulfate (E1S), primarily in the liver, by the action of oestrogen sulfotransferase (EST), and E1S can be converted to E1 via the action of the STS pathway.
It is important to note that even after ovarian production of estrodiol has stopped (around menopause), keeping cortisol levels stable and progesterone levels adequate provides the basis for the body to produce estrone as the primary postmenopausal estrogen which will keep postmenopausal symptoms (bone thinning, thinning vaginal walls, low libido, etc.
Estrone binds preferentially to ER [alpha], whereas estriol binds to ER [beta].
Consider testosterone and estrone, whose structures are shown side by side in Figure 1.
And it is a bit disconcerting to learn that you have no more control over your life than the male flounders in New York City's Jamaica Bay, which have become feminized because of the high levels of the female hormone estrone or other estrogenic chemicals discovered in the waterway.
Diosgenin is isolated from these plants and is converted in the lab to all of the human hormones: estradiol, estriol, estrone, progesterone, testosterone, DHEA, and pregnenolone.
Your body produces several estrogens--17-beta-estradiol, estrone, and estriol--as well as progesterone, testosterone, and other hormones.