estrogenism

estrogenism

the disease state caused by the continued ingestion of low but toxic levels of estrogens. This may be iatrogenic in origin in companion animals but the most important occurrence is in farm animals pastured on plants containing phytoestrogens. The signs are those related to endometrial hyperplasia and vaginal tumefaction, including long-term infertility and rectal prolapse, especially in pigs, uterine prolapse, especially in ewes, and feminization of male castrates.

Dogs are particularly susceptible to the myelotoxic effects of estrogens and high dose or prolonged administration causes severe bone marrow depression with thrombocytopenia, then leukopenia and anemia.