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estrogen receptor assay |
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estrogen receptor assay, a microscopic examination of breast tumor tissue used to determine the probable response of a tumor to endocrine therapy. estrogen receptor assay Oncology The ER is a protein found in high concentrations in the cytoplasm of breast, uterus, hypothalamus, and anterior hypophysis cells; ER levels are measured to determine a breast CA's potential for response
to hormonal manipulation–60% of breast CAs are 'estrogen positive';1⁄2 of ER-positive Pts respond favorably to anti-estrogen–tamoxifen citrate therapy, in contrast to
<1⁄3 of ER-negative Pts. See 'Flare' phenomenon. Cf Progesterone receptor assay. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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1 Because breast specimens are submitted for estrogen receptor assays as well as for HER2 assays, these intervals seemed the most appropriate recommendation at this time. When we acquired the robot, we had been performing most of the estrogen receptor assays for management of breast cancer cases in This combination of in vitro techniques includes the GST-pulldown assay (CARLA test), which detects interactions between ER and a coactivator; a competition binding assay that assesses ligand interactions with the receptor; a yeast-based estrogen receptor assay (YES); and a luciferase reporter assay in cultured MCF-7 cells that reveals transcriptional activation. |
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