esthesioneuroblastoma


Also found in: Encyclopedia.

es·the·si·o·neu·ro·blas·to·ma

(es-thē'zē-ō-nū'ō-blas-tō'mă),
A neoplasm of immature, poorly differentiated neuronal cells believed to arise from neuroepithelial precursors.
[esthesio- + neuroblastoma]

esthesioneuroblastoma

A rare malignant neuroectodermal tumour of the nasal cavity in the retrobulbar region, middle cranial fossa, near the cribriform plate. It is thought to arise from the olfactory membrane of the sinonasal tract.

Clinical findings
Bimodal age distribution, affecting those in the 2nd and 6th decades of life; presents as a unilateral nasal obstruction, epistaxis, anosmia and headache, accompanied by nonspecific symptoms similar to other intranasal lesions—i.e., congestion, rhinorrhoea.
 
DiffDx
Small round cell malignancies that occur in the sinonasal tract—e.g., sinonasal undifferentiated carcinoma, lymphoma, rhabdomyosarcoma and neuroendocrine carcinomas.

Prognosis
5-year survival 50–60%; late recurrence is common. Hyams’ grading system is used for grading; it incorporates architecture, rosette formation, mitoses, necrosis and pleomorphism, and correlates with survival.

esthesioneuroblastoma

Olfactory neuroblastoma ENT A tumor of the nasal cavity, retrobulbar region or middle cranial fossa Clinical Nonspecific, similar to other intranasal lesions, ie congestion, rhinorrhea DiffDx Lymphoma, plasmacytoma, embryonal rhabdomyosarcoma Prognosis 5-yr survival 50-60%; late recurrence is common

esthesioneuroblastoma

see olfactory neuroblastoma.
References in periodicals archive ?
2) Benoit et al showed that esthesioneuroblastoma was the second most common malignancy of the nasal cavity in children, second only to RMS.
SNUC can be distinguished from esthesioneuroblastomas by the histologic occurrence of intercellular fibrils and periodic Homer Wright rosettes in esthesioneuroblastomas.
Esthesioneuroblastoma and sinonasal undifferentiated carcinoma: Impact of histological grading and clinical staging on survival and prognosis.
Esthesioneuroblastoma is an uncommon upper nasal cavity malignant tumor that arises from the olfactory neuroepithelium.
Malignant lesions include squamous cell carcinoma, esthesioneuroblastoma, salivary gland tumor, sarcoma, and ameloblastoma.
In addition, immunohistochemical study is used to differentiate extramedullary plasmacytoma from benign reactive plasmacytosis as well as other malignant disorders, such as undifferentiated carcinoma, melanoma, and esthesioneuroblastoma.
esthesioneuroblastoma and angiofibroma), and others can be excluded by histopathology and immunohistochemistry.
Esthesioneuroblastoma and cervical lymph node metastases: Clinical and therapeutic implications.
Finally, malignant lesions to consider include squamous cell carcinomas, malignant melanomas, craniopharyngiomas, lymphomas, adenocarcinomas, adenoid cystic carcinomas, osteosarcomas, chondrosarcomas, nasopharyngeal carcinomas, and esthesioneuroblastomas.
8,10,17) Imaging of sinonasal hemangiopericytomas may be nonspecific, and these lesions should be differentiated from other types of tumors that involve the sinonasal area, such as esthesioneuroblastomas, adenoid cystic carcinomas, squamous cell carcinomas, and nasopharyngeal angiofibromas, among others.
There are several differential diagnoses for malignant peripheral nerve sheath tumors of the nose and paranasal sinuses--nasal polyps, mucoceles, gliomas, papillomas, esthesioneuroblastomas, sarcomas, carcinomas, and lymphomas.
Other neoplasms that can appear in the nose are angiofibromas, adenocarcinomas, melanomas, esthesioneuroblastomas, and neuroendocrine carcinomas.