essential thrombocytopenia

thrombocytopenia

decrease in number of platelets in circulating blood. See also purpura.

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alloimmune thrombocytopenia

due to alloantibodies generated in response to blood transfusions or to maternal alloimmunization. Caused by the exposure of the platelets of a newborn animal to platelet alloantibodies which are present in the colostrum of the dam. Occurs in piglets as a syndrome of spontaneous hemorrhage at a few days of age. See also immune-mediated thrombocytopenia (below).

consumption thrombocytopenia

excessive utilization of thrombocytes at hemorrhage sites causes significant reduction in circulating platelets.

drug-induced thrombocytopenia

that associated with a drug being administered. Some drugs named as causing thrombocytopenia are phenylbutazone, diphenylhydantoin, sulfonamides, digitoxin and phenothiazine tranquilizers.

essential thrombocytopenia

see megakaryocytic leukemia.

idiopathic thrombocytopenia

see immune-mediated thrombocytopenia (below).

immune-mediated thrombocytopenia

a loss of platelets caused by the presence of antiplatelet antibodies which can be demonstrated by the platelet factor-3 (PF-3) release test and immunofluorescence of megakaryocytes. Platelet production may be normal or impaired, also caused by antibodies directed against megakaryocytes. Includes alloimmune, autoimmune and some drug-induced thrombocytopenias.

infectious cyclic thrombocytopenia

recurring cycles of parasitemia and reduced numbers of thombocytes in the peripheral blood are seen in dogs infected with Anaplasmaplatys. Clinical signs are rarely observed, but coinfection may potentiate clinical disease caused by E. canis.

isoimmune thrombocytopenia

see alloimmune thrombocytopenia (above).

myelophthisic thrombocytopenia

that due to neoplastic invasion of the bone marrow.

surface-induced thrombocytopenia

a form of nonimmune-mediated platelet destruction caused by exposure of platelets to a damaged or artificial surface.

thrombin-induced thrombocytopenia

thrombin stimulates platelet aggregation and reduces circulating numbers.

vaccine-induced thrombocytopenia

live-virus vaccines may be associated with a transient, nonimmunogenic aggregation and reduction in numbers of platelets.

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essential thrombocytopenia

A condition of young adults with thrombotic complications occurring in <¹⁄₂ of cases, associated with vasocclusive headaches, erythromelalgia Treatment Conservative, anegrelide if Sx