calicheamicin

(redirected from esperamicin)
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calicheamicin

Any of a family of antitumour antibiotics derived from Micromonospora calichensis and Actinomadura verrucosospora, which have 4000-fold greater antitumoural activity than adriamycin, share a motif of double-triple-double carbon bonds (a so-called enediyene) and cleave DNA in a double-stranded fashion at specific DNA sequences.
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Long has enjoyed a distinguished career at Bristol-Myers Squibb where his research focused primarily on identifying the mechanisms of action of novel natural products identified as having anticancer activities, which included elsamycin, gilvocarcin, eleutherobin, esperamicin, rebeccamycin, a rebeccamycin analog, and epothilone.